Dopamine receptors

Kim A. Neve

doi:10.1007/978-1-59259-852-6_1

Dopamine receptors

Kim A. Neve

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Beginning with the initial suggestion that antipsychotic neuroleptic drugs block dopamine receptors (1), and continuing with the demonstration that the affinity of antipsychotic drugs for dopamine receptors is highly correlated with clinical potency (2,3), and that the density of [³H]neuroleptic- labeled dopamine receptors is enhanced in postmortem brain tissue of schizophrenics (4), the study of dopamine receptors has been inextricably linked with hypotheses for the mechanism of action of antipsychotic drugs and the etiology of schizophrenia. As described in other chapters in this volume, the role of dopamine in numerous other neuropsychiatric disorders, such as parkinsonism, attention deficit hyperactivity disorder, and addiction, has made consideration of the properties of dopamine receptor subtypes important for attempts to provide improved pharmacological treatments for these disorders. This chapter summarizes the molecular cloning of the five mammalian dopamine receptor subtypes, and reviews their structural, pharmacological, signaling, and regulatory properties.

Original language	English (US)
Title of host publication	Dopamine and Glutamate in Psychiatric Disorders
Publisher	Humana Press
Pages	3-43
Number of pages	41
ISBN (Print)	9781588293251
DOIs	https://doi.org/10.1007/978-1-59259-852-6_1
State	Published - 2005
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-59259-852-6_1

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AB - Beginning with the initial suggestion that antipsychotic neuroleptic drugs block dopamine receptors (1), and continuing with the demonstration that the affinity of antipsychotic drugs for dopamine receptors is highly correlated with clinical potency (2,3), and that the density of [3H]neuroleptic- labeled dopamine receptors is enhanced in postmortem brain tissue of schizophrenics (4), the study of dopamine receptors has been inextricably linked with hypotheses for the mechanism of action of antipsychotic drugs and the etiology of schizophrenia. As described in other chapters in this volume, the role of dopamine in numerous other neuropsychiatric disorders, such as parkinsonism, attention deficit hyperactivity disorder, and addiction, has made consideration of the properties of dopamine receptor subtypes important for attempts to provide improved pharmacological treatments for these disorders. This chapter summarizes the molecular cloning of the five mammalian dopamine receptor subtypes, and reviews their structural, pharmacological, signaling, and regulatory properties.

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Dopamine receptors

Abstract

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