Dopamine Infusion in Man. Plasma Catecholamine Levels and Pharmacokinetics

P. O. Järnberg, L. Bengtsson, J. Ekstrand, B. Hamberger

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Dopamine is widely used in the treatment of hypotensive conditions and/or impending renal failure, but the plasma levels of dopamine and other catecholamines in association with dopamine infusion are not known. Plasma catecholamines and dopamine pharmacokinetics during and after dopamine infusion were therefore studied in man. Two and 5 μg ‐ kg‐1 ‐ min‐1 of dopamine were infused for 30 min in two groups of five patients. Dose‐dependent mean steady state levels with fairly large interindividual variations were reached within 5 min. Elimination of dopamine from plasma after termination of infusion had a biphasic course with t 1/2 around 1 min and t 1/2 β about 9 min in both groups. Noradrenaline plasma levels and blood pressure increased significantly in the 5 μg group. It is suggested that the vasoconstriction with deleterious effects on tissue perfusion, seen in conjunction with high‐dose dopamine infusion, may be due to increased noradrenaline levels.

Original languageEnglish (US)
Pages (from-to)328-331
Number of pages4
JournalActa Anaesthesiologica Scandinavica
Volume25
Issue number4
DOIs
StatePublished - Aug 1981

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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