Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K. Thanos; Rahila Habibi; Michael Michaelides; Ujval B. Patel; Katherine Suchland; Brenda J. Anderson; John K. Robinson; Gene Jack Wang; David K. Grandy; Nora D. Volkow

doi:10.1016/j.bbr.2009.10.020

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K. Thanos, Rahila Habibi, Michael Michaelides, Ujval B. Patel, Katherine Suchland, Brenda J. Anderson, John K. Robinson, Gene Jack Wang, David K. Grandy, Nora D. Volkow

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R^+/+), both heterozygous (D4R^+/-) and knockout (D4R^-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

Original language	English (US)
Pages (from-to)	508-511
Number of pages	4
Journal	Behavioural Brain Research
Volume	207
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.10.020
State	Published - Mar 5 2010
Externally published	Yes

Keywords

Addiction
Cognition
Reinforcement
Reward

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2009.10.020

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@article{05233b4f51684b83b243723c40d7825f,

title = "Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine",

abstract = "In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.",

keywords = "Addiction, Cognition, Reinforcement, Reward",

author = "Thanos, {Panayotis K.} and Rahila Habibi and Michael Michaelides and Patel, {Ujval B.} and Katherine Suchland and Anderson, {Brenda J.} and Robinson, {John K.} and Wang, {Gene Jack} and Grandy, {David K.} and Volkow, {Nora D.}",

note = "Funding Information: Support contributed by: NIAAA (Intramural Research Program, LNI), the NIH IRTA program, the Stony Brook URECA program and the BNL SULI program . We also thank N. Londono for her assistance with the D4 mouse breeding colony.",

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doi = "10.1016/j.bbr.2009.10.020",

language = "English (US)",

volume = "207",

pages = "508--511",

journal = "Behavioural Brain Research",

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publisher = "Elsevier",

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T1 - Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

AU - Thanos, Panayotis K.

AU - Habibi, Rahila

AU - Michaelides, Michael

AU - Patel, Ujval B.

AU - Suchland, Katherine

AU - Anderson, Brenda J.

AU - Robinson, John K.

AU - Wang, Gene Jack

AU - Grandy, David K.

AU - Volkow, Nora D.

N1 - Funding Information: Support contributed by: NIAAA (Intramural Research Program, LNI), the NIH IRTA program, the Stony Brook URECA program and the BNL SULI program . We also thank N. Londono for her assistance with the D4 mouse breeding colony.

PY - 2010/3/5

Y1 - 2010/3/5

N2 - In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

AB - In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

KW - Addiction

KW - Cognition

KW - Reinforcement

KW - Reward

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JO - Behavioural Brain Research

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Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Abstract

Keywords

ASJC Scopus subject areas

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