Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K. Thanos, Rahila Habibi, Michael Michaelides, Ujval B. Patel, Katherine Suchland, Brenda J. Anderson, John K. Robinson, Gene Jack Wang, David K. Grandy, Nora D. Volkow

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

    Original languageEnglish (US)
    Pages (from-to)508-511
    Number of pages4
    JournalBehavioural Brain Research
    Volume207
    Issue number2
    DOIs
    StatePublished - Mar 5 2010

    Keywords

    • Addiction
    • Cognition
    • Reinforcement
    • Reward

    ASJC Scopus subject areas

    • Behavioral Neuroscience

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  • Cite this

    Thanos, P. K., Habibi, R., Michaelides, M., Patel, U. B., Suchland, K., Anderson, B. J., Robinson, J. K., Wang, G. J., Grandy, D. K., & Volkow, N. D. (2010). Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine. Behavioural Brain Research, 207(2), 508-511. https://doi.org/10.1016/j.bbr.2009.10.020