In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
|Original language||English (US)|
|Number of pages||4|
|Journal||Behavioural Brain Research|
|State||Published - Mar 5 2010|
ASJC Scopus subject areas
- Behavioral Neuroscience