Donor preconditioning with a calcineurin inhibitor improves outcome in rat syngeneic kidney transplantation

Fuad S. Shihab, William M. Bennett, Takeshi F. Andoh

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Ischemia-reperfusion injury (IRI) in the early posttransplant period affects immediate graft function and late allograft dysfunction. This study determines the influence of pharmacologic preconditioning with a calcineurin inhibitor on IRI in a syngeneic F344 rat kidney transplant model. Donor rats were pretreated with one dose of cyclosporine (10 mg/kg) or tacrolimus (1 mg/kg) administered at 24 hr or 7 days before being subjected to 2 hr of cold ischemia and then transplanted. Pharmacologic preconditioning significantly improved renal function, as assessed by serum creatinine and inulin clearance, and histologic score versus vehicle-treated rats. There were no differences between cyclosporine and tacrolimus in the measured outcomes. This renoprotective effect, although not complete, was seen with only one dose of calcineurin inhibitor, and the effect was sustained for at least 7 days before IRI. This approach may represent a viable pharmacologic intervention to decrease IRI at the time of organ transplantation.

Original languageEnglish (US)
Pages (from-to)326-329
Number of pages4
JournalTransplantation
Volume87
Issue number3
DOIs
StatePublished - Feb 15 2009

ASJC Scopus subject areas

  • Transplantation

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