Donation after cardiac death: the University of Wisconsin experience.

Anthony M. D'Alessandro, Luis A. Fernandez, L. Thomas Chin, Brian D. Shames, Nicole A. Turgeon, David Scott, Antonio Di Carlo, Yolanda T. Becker, Jon S. Odorico, Stuart J. Knechtle, Robert B. Love, John D. Pirsch, Bryan N. Becker, Alexandru I. Musat, Munci Kalayoglu, Hans W. Sollinger

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

OBJECTIVES: The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors. METHODS: From January 1984 through July 2000, outcomes of 382 DCD kidneys were compared to 1,089 kidneys (SPK) transplants and 36 liver transplants from DCD donors were compared to 455 SPK and 510 liver transplants from DBD donors. Likewise, 31 simultaneous pancreas-kidneys transplants from DBD donors. RESULTS: The rate of delayed graft function (DGF) was higher in kidneys transplanted from DCD donors (27.5% versus 21.3%, p=0.01). Likewise, discharge creatinines were higher in recipients of DCD kidneys (1.9 mg/dL versus 1.7 mg/dL, p=0.001). There was no difference in 10-year graft survival between DCD and DBD recipients (45.0% versus 48.0%, p=0.054). No difference in 5-year pancreatic and renal allograft survival was seen after SPK from DCD or DBD donors. After liver transplantation, biliary strictures were higher in recipients of DCD livers (13.9% versus 8.0%, p=0.03). Likewise, 3-year patient and graft survivals were lower for recipients of DCD livers (65.8% versus 84.9%, p=0.01; and 58.6% versus 76.9%, p=0.006). CONCLUSIONS: This large experience with transplantation from DCD donors demonstrates that similar patient and graft survivals can be expected when compared to recipients of organs from DBD donors.

Original languageEnglish (US)
Pages (from-to)68-71
Number of pages4
JournalAnnals of transplantation : quarterly of the Polish Transplantation Society
Volume9
Issue number1
StatePublished - 2004
Externally publishedYes

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Brain Death
Tissue Donors
Kidney
Graft Survival
Transplants
Tissue and Organ Procurement
Liver
Liver Transplantation
Delayed Graft Function
Pancreas Transplantation
Allografts
Pancreas
Creatinine
Pathologic Constriction
Transplantation
Lung

Cite this

D'Alessandro, A. M., Fernandez, L. A., Chin, L. T., Shames, B. D., Turgeon, N. A., Scott, D., ... Sollinger, H. W. (2004). Donation after cardiac death: the University of Wisconsin experience. Annals of transplantation : quarterly of the Polish Transplantation Society, 9(1), 68-71.

Donation after cardiac death : the University of Wisconsin experience. / D'Alessandro, Anthony M.; Fernandez, Luis A.; Chin, L. Thomas; Shames, Brian D.; Turgeon, Nicole A.; Scott, David; Di Carlo, Antonio; Becker, Yolanda T.; Odorico, Jon S.; Knechtle, Stuart J.; Love, Robert B.; Pirsch, John D.; Becker, Bryan N.; Musat, Alexandru I.; Kalayoglu, Munci; Sollinger, Hans W.

In: Annals of transplantation : quarterly of the Polish Transplantation Society, Vol. 9, No. 1, 2004, p. 68-71.

Research output: Contribution to journalArticle

D'Alessandro, AM, Fernandez, LA, Chin, LT, Shames, BD, Turgeon, NA, Scott, D, Di Carlo, A, Becker, YT, Odorico, JS, Knechtle, SJ, Love, RB, Pirsch, JD, Becker, BN, Musat, AI, Kalayoglu, M & Sollinger, HW 2004, 'Donation after cardiac death: the University of Wisconsin experience.', Annals of transplantation : quarterly of the Polish Transplantation Society, vol. 9, no. 1, pp. 68-71.
D'Alessandro, Anthony M. ; Fernandez, Luis A. ; Chin, L. Thomas ; Shames, Brian D. ; Turgeon, Nicole A. ; Scott, David ; Di Carlo, Antonio ; Becker, Yolanda T. ; Odorico, Jon S. ; Knechtle, Stuart J. ; Love, Robert B. ; Pirsch, John D. ; Becker, Bryan N. ; Musat, Alexandru I. ; Kalayoglu, Munci ; Sollinger, Hans W. / Donation after cardiac death : the University of Wisconsin experience. In: Annals of transplantation : quarterly of the Polish Transplantation Society. 2004 ; Vol. 9, No. 1. pp. 68-71.
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abstract = "OBJECTIVES: The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors. METHODS: From January 1984 through July 2000, outcomes of 382 DCD kidneys were compared to 1,089 kidneys (SPK) transplants and 36 liver transplants from DCD donors were compared to 455 SPK and 510 liver transplants from DBD donors. Likewise, 31 simultaneous pancreas-kidneys transplants from DBD donors. RESULTS: The rate of delayed graft function (DGF) was higher in kidneys transplanted from DCD donors (27.5{\%} versus 21.3{\%}, p=0.01). Likewise, discharge creatinines were higher in recipients of DCD kidneys (1.9 mg/dL versus 1.7 mg/dL, p=0.001). There was no difference in 10-year graft survival between DCD and DBD recipients (45.0{\%} versus 48.0{\%}, p=0.054). No difference in 5-year pancreatic and renal allograft survival was seen after SPK from DCD or DBD donors. After liver transplantation, biliary strictures were higher in recipients of DCD livers (13.9{\%} versus 8.0{\%}, p=0.03). Likewise, 3-year patient and graft survivals were lower for recipients of DCD livers (65.8{\%} versus 84.9{\%}, p=0.01; and 58.6{\%} versus 76.9{\%}, p=0.006). CONCLUSIONS: This large experience with transplantation from DCD donors demonstrates that similar patient and graft survivals can be expected when compared to recipients of organs from DBD donors.",
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T1 - Donation after cardiac death

T2 - the University of Wisconsin experience.

AU - D'Alessandro, Anthony M.

AU - Fernandez, Luis A.

AU - Chin, L. Thomas

AU - Shames, Brian D.

AU - Turgeon, Nicole A.

AU - Scott, David

AU - Di Carlo, Antonio

AU - Becker, Yolanda T.

AU - Odorico, Jon S.

AU - Knechtle, Stuart J.

AU - Love, Robert B.

AU - Pirsch, John D.

AU - Becker, Bryan N.

AU - Musat, Alexandru I.

AU - Kalayoglu, Munci

AU - Sollinger, Hans W.

PY - 2004

Y1 - 2004

N2 - OBJECTIVES: The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors. METHODS: From January 1984 through July 2000, outcomes of 382 DCD kidneys were compared to 1,089 kidneys (SPK) transplants and 36 liver transplants from DCD donors were compared to 455 SPK and 510 liver transplants from DBD donors. Likewise, 31 simultaneous pancreas-kidneys transplants from DBD donors. RESULTS: The rate of delayed graft function (DGF) was higher in kidneys transplanted from DCD donors (27.5% versus 21.3%, p=0.01). Likewise, discharge creatinines were higher in recipients of DCD kidneys (1.9 mg/dL versus 1.7 mg/dL, p=0.001). There was no difference in 10-year graft survival between DCD and DBD recipients (45.0% versus 48.0%, p=0.054). No difference in 5-year pancreatic and renal allograft survival was seen after SPK from DCD or DBD donors. After liver transplantation, biliary strictures were higher in recipients of DCD livers (13.9% versus 8.0%, p=0.03). Likewise, 3-year patient and graft survivals were lower for recipients of DCD livers (65.8% versus 84.9%, p=0.01; and 58.6% versus 76.9%, p=0.006). CONCLUSIONS: This large experience with transplantation from DCD donors demonstrates that similar patient and graft survivals can be expected when compared to recipients of organs from DBD donors.

AB - OBJECTIVES: The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors. METHODS: From January 1984 through July 2000, outcomes of 382 DCD kidneys were compared to 1,089 kidneys (SPK) transplants and 36 liver transplants from DCD donors were compared to 455 SPK and 510 liver transplants from DBD donors. Likewise, 31 simultaneous pancreas-kidneys transplants from DBD donors. RESULTS: The rate of delayed graft function (DGF) was higher in kidneys transplanted from DCD donors (27.5% versus 21.3%, p=0.01). Likewise, discharge creatinines were higher in recipients of DCD kidneys (1.9 mg/dL versus 1.7 mg/dL, p=0.001). There was no difference in 10-year graft survival between DCD and DBD recipients (45.0% versus 48.0%, p=0.054). No difference in 5-year pancreatic and renal allograft survival was seen after SPK from DCD or DBD donors. After liver transplantation, biliary strictures were higher in recipients of DCD livers (13.9% versus 8.0%, p=0.03). Likewise, 3-year patient and graft survivals were lower for recipients of DCD livers (65.8% versus 84.9%, p=0.01; and 58.6% versus 76.9%, p=0.006). CONCLUSIONS: This large experience with transplantation from DCD donors demonstrates that similar patient and graft survivals can be expected when compared to recipients of organs from DBD donors.

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