Dominant inheritance of cerebral gigantism

Jonathan (Jon) Zonana, Juan F. Sotos, Carolyn A. Romshe, Delbert A. Fisher, M. Jocelyn Elders, David L. Rimoin

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalThe Journal of Pediatrics
Volume91
Issue number2
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Sotos Syndrome
Inheritance Patterns
Growth
Intellectual Disability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Zonana, J. J., Sotos, J. F., Romshe, C. A., Fisher, D. A., Elders, M. J., & Rimoin, D. L. (1977). Dominant inheritance of cerebral gigantism. The Journal of Pediatrics, 91(2), 251-256. https://doi.org/10.1016/S0022-3476(77)80822-6

Dominant inheritance of cerebral gigantism. / Zonana, Jonathan (Jon); Sotos, Juan F.; Romshe, Carolyn A.; Fisher, Delbert A.; Elders, M. Jocelyn; Rimoin, David L.

In: The Journal of Pediatrics, Vol. 91, No. 2, 1977, p. 251-256.

Research output: Contribution to journalArticle

Zonana, JJ, Sotos, JF, Romshe, CA, Fisher, DA, Elders, MJ & Rimoin, DL 1977, 'Dominant inheritance of cerebral gigantism', The Journal of Pediatrics, vol. 91, no. 2, pp. 251-256. https://doi.org/10.1016/S0022-3476(77)80822-6
Zonana, Jonathan (Jon) ; Sotos, Juan F. ; Romshe, Carolyn A. ; Fisher, Delbert A. ; Elders, M. Jocelyn ; Rimoin, David L. / Dominant inheritance of cerebral gigantism. In: The Journal of Pediatrics. 1977 ; Vol. 91, No. 2. pp. 251-256.
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