Dominant inheritance of cerebral gigantism

Jonathan Zonana, Juan F. Sotos, Carolyn A. Romshe, Delbert A. Fisher, M. Jocelyn Elders, David L. Rimoin

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalThe Journal of pediatrics
Volume91
Issue number2
DOIs
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Zonana, J., Sotos, J. F., Romshe, C. A., Fisher, D. A., Elders, M. J., & Rimoin, D. L. (1977). Dominant inheritance of cerebral gigantism. The Journal of pediatrics, 91(2), 251-256. https://doi.org/10.1016/S0022-3476(77)80822-6