@article{c6a3a18e8f744c11808088da8d262307,
title = "Dominant inheritance of cerebral gigantism",
abstract = "Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.",
author = "Jonathan Zonana and Sotos, {Juan F.} and Romshe, {Carolyn A.} and Fisher, {Delbert A.} and Elders, {M. Jocelyn} and Rimoin, {David L.}",
note = "Funding Information: From the Divisions of Medical Genetics and Perinatal Biology, Departments of Pediatrics and Medicine, UCLA School of Medicine-Harbor General Hospital,{"} the Division of Endocrinology and Metabolism, Department of Pediatrics, College of Medicine, The Ohio State University and Children's Hospital Research Foundation; and Division of Endocrinology, Department of Pediatrics, University of A rkansas Medical Center. Presented in part at the 1975 Birth Defects Conference, Kansas City, Mo. Studies at Harbor General Hospital were supported by USPH RRO 0425 and HD-05624 and Birth Defects Center and research grants from the National Foundation~Mareh of Dimes, and the Easter Seal Research Foundation. Studies at the Children's Hospital, Columbus, Ohio were supported by the John W. Champion Center. Studies at the University of Arkansas were supported by United States Public Health Service grant AM 15901 and CA 13907. Dr. Zonana was supported by a National Foundation March of Dimes Postdoctoral Fellowship and United States Public Health Service Research Training Grants (5 TOI-HD 00417-03 and 5 T22-DE 00102-02). *Reprint address: Division of Medical Genetics, Harbor General Hospital, 1000 West Carson St., Torrance, CA 90509.",
year = "1977",
month = aug,
doi = "10.1016/S0022-3476(77)80822-6",
language = "English (US)",
volume = "91",
pages = "251--256",
journal = "The Journal of pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",
}