Dominant inheritance of cerebral gigantism

Jonathan Zonana, Juan F. Sotos, Carolyn A. Romshe, Delbert A. Fisher, M. Jocelyn Elders, David L. Rimoin

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalThe Journal of pediatrics
Issue number2
StatePublished - Aug 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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