LE DOGMATIL DANS LES DYSKINESIES TARDIVES

Translated title of the contribution: Dogmatil in tardive dyskinesia

J. Gerlach, D. E. Casey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Delayed dyskinesia (DD) apparently originates in the combination of an individual susceptibility and an antidopaminergic (neuroleptic) treatment. This combination may be responsible for: 1) relative hypersensitivity to dopamine with a rise in the number of dopaminergic receptors and/or depressed cholinergic activity (reversible DD); 2) a degenerative process, in prolonged treatments, resulting in a lowered threshold for emergence of dyskinetic manifestations (irreversible DD). Dogmatil, through selective blockade of D-2 dopaminergic receptors, is capable of reversing DD without exacerbating the parkinson-like syndrome. However, in predisposed patients, parkinson-like manifestations may be induced or exacerbated by dogmatil. Findings in animals suggest that the risk of including DD is less with dogmatil than with conventional neuroleptics. Nevertheless, long term clinical trials are needed to test this hypothesis.

Translated title of the contributionDogmatil in tardive dyskinesia
Original languageFrench
Pages (from-to)1369-1375
Number of pages7
JournalSemaine des Hopitaux
Volume61
Issue number19
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Dogmatil in tardive dyskinesia'. Together they form a unique fingerprint.

Cite this