Does the single-breath N2 test identify the smoker who will develop chronic airflow limitation?

A (Sonia) Buist, W. M. Vollmer, L. R. Johnson, L. E. McCamant

Research output: Contribution to journalArticle

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Abstract

We report here the results of a 9- to 11-yr follow-up of 2 cohorts in which spirometry and the single-breath N2 test were used throughout the follow-up period to determine the usefulness of the single-breath N2 test in identifying the smoker who is experiencing a rapid decline in FEV1 and is therefore likely to be at risk of developing chronic airflow limitation. The analyses are based on 734 subjects tested from 3 to 5 times over the follow-up period; 82 smokers developed an abnormal FEV1 during the follow-up period. Of these 71 (87%) had had an abnormal single-breath N2 test at some time prior to the FEV1 becoming abnormal. Of the single-breath N2 test variables, CC/TLC was the only one significantly associated wtih the rate of decline of FEV1 in both cohorts once adjustments were made for age, sex, height, and smoking. We conclude that the single-breath N2 test can be useful in identifying the smoker who is at risk of developing chronic airflow limitation. However, its usefulness is diminished by the high proportion of smokers who have mild functional abnormalities but do not progress to develop chronic airflow limitation. We also find that the single-breath N2 test does not appear to have a useful predictive value in nonsmokers.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
JournalAmerican Review of Respiratory Disease
Volume137
Issue number2
StatePublished - 1988

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Breath Tests
Social Adjustment
Spirometry
Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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Does the single-breath N2 test identify the smoker who will develop chronic airflow limitation? / Buist, A (Sonia); Vollmer, W. M.; Johnson, L. R.; McCamant, L. E.

In: American Review of Respiratory Disease, Vol. 137, No. 2, 1988, p. 293-301.

Research output: Contribution to journalArticle

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