Does the microbiome play a causal role in spondyloarthritis?

James T. Rosenbaum, Phoebe Lin, Mark Asquith, Mary Ellen Costello, Tony J. Kenna, Matthew A. Brown

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.

Original languageEnglish (US)
Pages (from-to)763-767
Number of pages5
JournalClinical Rheumatology
Volume33
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Inflammatory bowel disease
  • Microbiome
  • Spondyloarthritis

ASJC Scopus subject areas

  • Rheumatology

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