Does salvage radiation therapy change the biology of recurrent prostate cancer based on PSA doubling times? Results from the SEARCH database

Roberto L. Muller, Joseph C. Presti, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher Amling, Stephen J. Freedland

Research output: Contribution to journalArticle

Abstract

Objective: To investigate whether salvage radiation therapy (SRT) may promote prostate cancer (PCa) transformation to more aggressive phenotypes. To accomplish that, we identified men who underwent SRT after radical prostatectomy for PCa and failed SRT. PSA doubling time (PSADT) was used as a surrogate endpoint for cancer aggressiveness. We compared PSADT calculated before start of SRT and after SRT failure. Methods: Of 287 men in the SEARCH database since 1988 who underwent SRT, we detected 78 with SRT failure defined as PSA

Original languageEnglish (US)
Pages (from-to)1105-1110
Number of pages6
JournalUrology
Volume79
Issue number5
DOIs
StatePublished - May 2012

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Salvage Therapy
Prostatic Neoplasms
Radiotherapy
Databases
Prostatectomy
Biomarkers
Phenotype

ASJC Scopus subject areas

  • Urology

Cite this

Does salvage radiation therapy change the biology of recurrent prostate cancer based on PSA doubling times? Results from the SEARCH database. / Muller, Roberto L.; Presti, Joseph C.; Aronson, William J.; Terris, Martha K.; Kane, Christopher J.; Amling, Christopher; Freedland, Stephen J.

In: Urology, Vol. 79, No. 5, 05.2012, p. 1105-1110.

Research output: Contribution to journalArticle

Muller, Roberto L. ; Presti, Joseph C. ; Aronson, William J. ; Terris, Martha K. ; Kane, Christopher J. ; Amling, Christopher ; Freedland, Stephen J. / Does salvage radiation therapy change the biology of recurrent prostate cancer based on PSA doubling times? Results from the SEARCH database. In: Urology. 2012 ; Vol. 79, No. 5. pp. 1105-1110.
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AU - Freedland, Stephen J.

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