Does reversal of ischemia on diffusion-weighted imaging reflect higher apparent diffusion coefficient values?

Helmi L. Lutsep, Gary M. Nesbit, Richard M. Berger, William R. Coshow

Research output: Contribution to journalArticle

17 Scopus citations


This study investigated whether ischemia on diffusion-weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks. A 100.01-cm 3 left frontoparietal stroke on baseline DWI was only 18.11 cm3 (18%) on 4-week fluid attenuated inversion recovery. The mean ADC was 7.43 x× 10-3 mm2/s in the 6 regions that reversed and 7.31 x× 10-3 mm2/s in the 6 regions that persisted (P <. 036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalJournal of Neuroimaging
Issue number3
StatePublished - Jan 1 2001



  • Apparent diffusion coefficient
  • Cerebral ischemia
  • Diffusion-weighted imaging
  • Fluid attenuated inversion recovery
  • Thrombolytic treatment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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