TY - JOUR
T1 - Does olfactory function improve after endoscopic sinus surgery?
AU - Litvack, Jamie R.
AU - Mace, Jess
AU - Smith, Timothy L.
N1 - Funding Information:
This publication was made possible with support from NIH/NIDCD R01 DC005805 (PI: T. L. Smith) and the Oregon Clinical and Translational Research Institute (OCTRI); grant number UL1 RR024140 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH); and NIH Roadmap for Medical Research.
Funding Information:
Jamie R. Litvack , none; Jess Mace , grant funding: NIH/NIDCD; Timothy L. Smith , grant funding: NIH/NIDCD; consultant: Sinexus, Inc.
PY - 2009/3
Y1 - 2009/3
N2 - Objective: To examine the impact of endoscopic sinus surgery (ESS) on olfactory impairment in patients with chronic rhinosinusitis (CRS) over intermediate and long-term follow-up. We hypothesized that patients with mild olfactory dysfunction (hyposmia) would benefit from ESS, whereas patients with severe olfactory dysfunction (anosmia) would not. Study Design: Prospective, multi-institutional cohort study. Subjects and Methods: A total of 111 patients presenting for ESS for treatment of CRS were examined preoperatively, and at 6 and 12 months postoperatively. Demographic, comorbidity, and Smell Identification Test (SIT) data were collected at each time point. Univariate and multivariate analyses were performed. Results: The prevalence of gender-adjusted olfactory dysfunction prior to surgery was 67.5 percent. Surprisingly, hyposmic patients did not significantly improve after surgery. In contrast, patients with anosmia significantly improved after ESS (baseline, 6-month SIT scores: 9.7 ± 2.0, 21.3 ± 11.2; P = 0.001). Improvement was sustained at 12-month follow-up (21.7 ± 10.7; P = 0.001). Multivariate linear regression analysis showed that baseline olfactory category and nasal polyposis were significantly associated with improvement in postoperative olfactory function (P = 0.035, P = 0.002). Conclusion: Contrary to our hypotheses, patients with severe olfactory dysfunction significantly improved after ESS and sustained improvement over time, whereas patients with mild olfactory dysfunction did not.
AB - Objective: To examine the impact of endoscopic sinus surgery (ESS) on olfactory impairment in patients with chronic rhinosinusitis (CRS) over intermediate and long-term follow-up. We hypothesized that patients with mild olfactory dysfunction (hyposmia) would benefit from ESS, whereas patients with severe olfactory dysfunction (anosmia) would not. Study Design: Prospective, multi-institutional cohort study. Subjects and Methods: A total of 111 patients presenting for ESS for treatment of CRS were examined preoperatively, and at 6 and 12 months postoperatively. Demographic, comorbidity, and Smell Identification Test (SIT) data were collected at each time point. Univariate and multivariate analyses were performed. Results: The prevalence of gender-adjusted olfactory dysfunction prior to surgery was 67.5 percent. Surprisingly, hyposmic patients did not significantly improve after surgery. In contrast, patients with anosmia significantly improved after ESS (baseline, 6-month SIT scores: 9.7 ± 2.0, 21.3 ± 11.2; P = 0.001). Improvement was sustained at 12-month follow-up (21.7 ± 10.7; P = 0.001). Multivariate linear regression analysis showed that baseline olfactory category and nasal polyposis were significantly associated with improvement in postoperative olfactory function (P = 0.035, P = 0.002). Conclusion: Contrary to our hypotheses, patients with severe olfactory dysfunction significantly improved after ESS and sustained improvement over time, whereas patients with mild olfactory dysfunction did not.
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U2 - 10.1016/j.otohns.2008.12.006
DO - 10.1016/j.otohns.2008.12.006
M3 - Article
C2 - 19248934
AN - SCOPUS:60549085750
SN - 0194-5998
VL - 140
SP - 312
EP - 319
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 3
ER -