Does loud sound influence the intracochlear oxygen tension?

Alfred Nuttall, Elisabeth Hultcrantz, Merle Lawrence

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effect of loud sound on the perilymphatic oxygen tension was studied in anesthetized guinea pigs. Pure tone (4 kHz) and broad-band noise were given at 85-130 dB SPL for 3-8 min. No effects were seen either in the animals exposed to pure tone or in the animals exposed to 85 dB broad-band noise. In the animals exposed to noise at 130 dB SPL both increases and decreases of perilymphatic oxygen were measured but the changes were only of about 12% or less. The response to anoxia was normal. In animals with hypotension (O2 fluctuated with the blood pressure. When the sound was delivered directly into the opened bulla the measured PO2 dropped immediately but was found to be caused by the cooling effect of an air current produced by the noise. Flushing the opened bulla with nitrogen, air or oxygen caused the same temperature-induced drop of measured PO2 . The results and the artifacts are discussed.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalHearing Research
Volume5
Issue number2-3
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Noise
Oxygen
Blister
Air
Hypotension
Artifacts
Guinea Pigs
Nitrogen
Blood Pressure
Temperature

Keywords

  • cochlear temperature
  • guinea pig
  • loud sound
  • perilymphatic oxygen tension

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Does loud sound influence the intracochlear oxygen tension? / Nuttall, Alfred; Hultcrantz, Elisabeth; Lawrence, Merle.

In: Hearing Research, Vol. 5, No. 2-3, 1981, p. 285-293.

Research output: Contribution to journalArticle

Nuttall, Alfred ; Hultcrantz, Elisabeth ; Lawrence, Merle. / Does loud sound influence the intracochlear oxygen tension?. In: Hearing Research. 1981 ; Vol. 5, No. 2-3. pp. 285-293.
@article{8046c152508748aca4ca5edf854806dd,
title = "Does loud sound influence the intracochlear oxygen tension?",
abstract = "The effect of loud sound on the perilymphatic oxygen tension was studied in anesthetized guinea pigs. Pure tone (4 kHz) and broad-band noise were given at 85-130 dB SPL for 3-8 min. No effects were seen either in the animals exposed to pure tone or in the animals exposed to 85 dB broad-band noise. In the animals exposed to noise at 130 dB SPL both increases and decreases of perilymphatic oxygen were measured but the changes were only of about 12{\%} or less. The response to anoxia was normal. In animals with hypotension (O2 fluctuated with the blood pressure. When the sound was delivered directly into the opened bulla the measured PO2 dropped immediately but was found to be caused by the cooling effect of an air current produced by the noise. Flushing the opened bulla with nitrogen, air or oxygen caused the same temperature-induced drop of measured PO2 . The results and the artifacts are discussed.",
keywords = "cochlear temperature, guinea pig, loud sound, perilymphatic oxygen tension",
author = "Alfred Nuttall and Elisabeth Hultcrantz and Merle Lawrence",
year = "1981",
doi = "10.1016/0378-5955(81)90052-6",
language = "English (US)",
volume = "5",
pages = "285--293",
journal = "Hearing Research",
issn = "0378-5955",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Does loud sound influence the intracochlear oxygen tension?

AU - Nuttall, Alfred

AU - Hultcrantz, Elisabeth

AU - Lawrence, Merle

PY - 1981

Y1 - 1981

N2 - The effect of loud sound on the perilymphatic oxygen tension was studied in anesthetized guinea pigs. Pure tone (4 kHz) and broad-band noise were given at 85-130 dB SPL for 3-8 min. No effects were seen either in the animals exposed to pure tone or in the animals exposed to 85 dB broad-band noise. In the animals exposed to noise at 130 dB SPL both increases and decreases of perilymphatic oxygen were measured but the changes were only of about 12% or less. The response to anoxia was normal. In animals with hypotension (O2 fluctuated with the blood pressure. When the sound was delivered directly into the opened bulla the measured PO2 dropped immediately but was found to be caused by the cooling effect of an air current produced by the noise. Flushing the opened bulla with nitrogen, air or oxygen caused the same temperature-induced drop of measured PO2 . The results and the artifacts are discussed.

AB - The effect of loud sound on the perilymphatic oxygen tension was studied in anesthetized guinea pigs. Pure tone (4 kHz) and broad-band noise were given at 85-130 dB SPL for 3-8 min. No effects were seen either in the animals exposed to pure tone or in the animals exposed to 85 dB broad-band noise. In the animals exposed to noise at 130 dB SPL both increases and decreases of perilymphatic oxygen were measured but the changes were only of about 12% or less. The response to anoxia was normal. In animals with hypotension (O2 fluctuated with the blood pressure. When the sound was delivered directly into the opened bulla the measured PO2 dropped immediately but was found to be caused by the cooling effect of an air current produced by the noise. Flushing the opened bulla with nitrogen, air or oxygen caused the same temperature-induced drop of measured PO2 . The results and the artifacts are discussed.

KW - cochlear temperature

KW - guinea pig

KW - loud sound

KW - perilymphatic oxygen tension

UR - http://www.scopus.com/inward/record.url?scp=0019797084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019797084&partnerID=8YFLogxK

U2 - 10.1016/0378-5955(81)90052-6

DO - 10.1016/0378-5955(81)90052-6

M3 - Article

C2 - 7309643

AN - SCOPUS:0019797084

VL - 5

SP - 285

EP - 293

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

IS - 2-3

ER -