Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?

Susan W. Trout, David B. Seifer

Research output: Contribution to journalArticle

56 Scopus citations


Objective: To determine the potential role of diminished ovarian reserve in unexplained habitual abortion. Design: Retrospective comparative analysis. Setting: University-based practice. Patient(s): Fifty-seven women who presented for evaluation of recurrent pregnancy loss (RPL). Intervention(s): The test group (n = 36) comprised women with unexplained RPL. The control group (n = 21) comprised women with a known cause of RPL. Mean age, parity, day 3 serum FSH and E2 levels, and presence or absence of a history of infertility were compared between groups. Main Outcome Measure(s): Day 3 serum FSH and E2 levels.Result(s): Both day 3 FSH and E2 levels were elevated in the unexplained group compared with the control group. When combined, FSH or E2 levels, or both, were elevated in 58% of the unexplained RPL group and 19% of the control group (odds ratio, 5.95 [95% CI, 1.7-21.3]; P<.004). Age, parity, and presence of infertility did not differ between groups. Conclusion(s): Women with unexplained RPL have a greater incidence of elevated day 3 serum FSH and E2 levels than do women with a known cause of RPL. Therefore, diminished ovarian reserve may contribute to recurrent pregnancy loss and should be considered part of the work-up for RPL. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalFertility and sterility
Issue number2
StatePublished - Aug 1 2000



  • Habitual abortion
  • Ovarian reserve
  • Recurrent pregnancy loss

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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