Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?

Susan W. Trout, David Seifer

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Objective: To determine the potential role of diminished ovarian reserve in unexplained habitual abortion. Design: Retrospective comparative analysis. Setting: University-based practice. Patient(s): Fifty-seven women who presented for evaluation of recurrent pregnancy loss (RPL). Intervention(s): The test group (n = 36) comprised women with unexplained RPL. The control group (n = 21) comprised women with a known cause of RPL. Mean age, parity, day 3 serum FSH and E2 levels, and presence or absence of a history of infertility were compared between groups. Main Outcome Measure(s): Day 3 serum FSH and E2 levels.Result(s): Both day 3 FSH and E2 levels were elevated in the unexplained group compared with the control group. When combined, FSH or E2 levels, or both, were elevated in 58% of the unexplained RPL group and 19% of the control group (odds ratio, 5.95 [95% CI, 1.7-21.3]; P2 levels than do women with a known cause of RPL. Therefore, diminished ovarian reserve may contribute to recurrent pregnancy loss and should be considered part of the work-up for RPL. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalFertility and Sterility
Volume74
Issue number2
DOIs
StatePublished - Aug 2000
Externally publishedYes

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Estradiol
Pregnancy
Serum
Control Groups
Habitual Abortion
Parity
Infertility
Odds Ratio
Outcome Assessment (Health Care)

Keywords

  • Habitual abortion
  • Ovarian reserve
  • Recurrent pregnancy loss

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? / Trout, Susan W.; Seifer, David.

In: Fertility and Sterility, Vol. 74, No. 2, 08.2000, p. 335-337.

Research output: Contribution to journalArticle

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