Do children with mental disorders have higher prevalence of hypovitaminosis D?

Mini Zhang, Keith Cheng, Robert Rope, Elizabeth Martin, Ajit Jetmalani

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Inadequate vitamin D level is associated with various adverse medical outcomes. There is a growing concern that insufficient vitamin D may play a role in the development of psychiatric symptoms. This study aims to answer the question: do children with mental disorders have a higher prevalence of hypovitaminosis D? A retrospective chart review examined 25 hydroxyvitamin D (25(OH)D) levels in youth ages 7 to 17 (n=67) at two Oregon psychiatric residential facilities. Vitamin D deficiency is defined as <20 ng/ml and insufficiency as <30 ng/ml. Diagnoses were organized into six categories. 25(OH)D levels were compared across genders and diagnostic groups using a two-sample t-test and ANOVA, respectively. Statistical differences in prevalence across diagnostic categories were calculated using a Pearson chi-square test. Using the data from Saintonge's NHANES III study on healthy US children for comparison, 21% of our cohorts were found to be vitamin D deficient and 64% insufficient, in contrast to 14% and 48%, respectively. While our results are not statistically significant, mainly because of small sample size, the overall mean 25(OH)D level in our cohort was insufficient (27.59 ± 9.35 ng/ml), compared to a sufficient mean value of 32.1 ng/ml in the general population. No statistical significant difference was found in the prevalence across diagnostic categories. This study found that children with psychiatric disorders might have a higher prevalence of hypovitaminosis D than the general pediatric population. Although a causal relationship between hypovitaminosis D and psychiatric disorders cannot be derived based on the study design, our study provides initial descriptive data on the prevalence of hypovitaminosis D in children with psychiatric disorders, which has not been previously reported to our knowledge. Prospective studies with a larger sample size and controlled variables would allow more precise analysis of the relationship between hypovitaminosis D and childhood mental disorders.

Original languageEnglish (US)
Article number159.v1
Number of pages1
JournalF1000Research
Volume2
DOIs
StatePublished - Jul 17 2013

Fingerprint

Vitamin D
Psychiatry
Child Psychiatry
Sample Size
Residential Facilities
Pediatrics
Vitamin D Deficiency
Nutrition Surveys
Chi-Square Distribution
Analysis of variance (ANOVA)
Mental Disorders
Population
Analysis of Variance
Neurodevelopmental Disorders
Prospective Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Do children with mental disorders have higher prevalence of hypovitaminosis D? / Zhang, Mini; Cheng, Keith; Rope, Robert; Martin, Elizabeth; Jetmalani, Ajit.

In: F1000Research, Vol. 2, 159.v1, 17.07.2013.

Research output: Contribution to journalArticle

Zhang, Mini ; Cheng, Keith ; Rope, Robert ; Martin, Elizabeth ; Jetmalani, Ajit. / Do children with mental disorders have higher prevalence of hypovitaminosis D?. In: F1000Research. 2013 ; Vol. 2.
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