DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B₁-Induced Formamidopyrimidine Guanine Adduct

Medicine & Life Sciences

• aflatoxin B1-formamidopyrimidine 100%
• 2,6-diamino-4-hydroxy-5-formamidopyrimidine 87%
• Aflatoxin B1 59%
• Guanine 52%
• DNA 17%
• DNA Repair 17%
• 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxyaflatoxin B1 16%
• 2,3-dihydro-2-(N(7)-guanyl)-3-hydroxyaflatoxin B1 14%
• Hot Temperature 9%
• DNA Glycosylases 9%
• Aflatoxins 8%
• Dietary Exposure 8%
• imidazole 8%
• Thermodynamics 7%
• Catalysis 7%
• Base Pairing 6%
• Freezing 6%
• Nucleotides 5%
• Hepatocellular Carcinoma 5%
• Carcinogenesis 4%
• Kinetics 4%
• Liver 3%

Chemical Compounds

• Formamidopyrimidine 74%
• Aflatoxin 56%
• DNA Sequence 46%
• Guanine 43%
• Adduct 31%
• Aflatoxin B1 16%
• Nucleotide 10%
• Thermal Stability 8%
• Modification 7%
• Intercalation Compound 5%
• Imidazole 5%
• Melting 5%
• Catalysis 4%
• Chemical Transformation 4%
• Thermodynamics 3%