DNA repair synthesis dependent on the uvrA,B gene products in toluene treated cells

R. E. Moses, E. E.M. Moody

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Ultraviolet irradiation of toluene treated Escherichia coli causes an inhibition of replicative DNA synthesis. This is followed by the appearance of nonconservative DNA repair synthesis which does not require either the polymerase or 5' → 3' exonucleolytic activities of DNA polymerase I. The repair synthesis may be catalyzed by DNA polymerase III activity but does not require a functional DNA polymerase II. The ultraviolet induced synthesis requires ATP and is dependent on a functional uvrA and uvrB gene product. However, other uvr gene products are not required for the synthesis. The recB function is also not required.

Original languageEnglish (US)
Pages (from-to)8055-8061
Number of pages7
JournalJournal of Biological Chemistry
Volume250
Issue number20
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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