DNA repair fidelity in stem cell maintenance, health, and disease

Chinnadurai Mani, P (Hemachandra) Reddy, Komaraiah Palle

    Research output: Contribution to journalReview article

    Abstract

    Stem cells are a sub population of cell types that form the foundation of our body, and have the potential to replicate, replenish and repair limitlessly to maintain the tissue and organ homeostasis. Increased lifetime and frequent replication set them vulnerable for both exogenous and endogenous agents-induced DNA damage compared to normal cells. To counter these damages and preserve genetic information, stem cells have evolved with various DNA damage response and repair mechanisms. Furthermore, upon experiencing irreparable DNA damage, stem cells mostly prefer early senescence or apoptosis to avoid the accumulation of damages. However, the failure of these mechanisms leads to various diseases, including cancer. Especially, given the importance of stem cells in early development, DNA repair deficiency in stem cells leads to various disabilities like developmental delay, premature aging, sensitivity to DNA damaging agents, degenerative diseases, etc. In this review, we have summarized the recent update about how DNA repair mechanisms are regulated in stem cells and their association with disease progression and pathogenesis.

    Original languageEnglish (US)
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    DNA Repair
    Stem Cells
    Maintenance
    Health
    DNA Damage
    DNA Repair-Deficiency Disorders
    Premature Aging
    Developmental Disabilities
    Disease Progression
    Homeostasis
    Apoptosis
    DNA
    Population
    Neoplasms

    Keywords

    • Disease
    • DNA damage and repair
    • Gene Therapy
    • Stem cells

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology

    Cite this

    DNA repair fidelity in stem cell maintenance, health, and disease. / Mani, Chinnadurai; Reddy, P (Hemachandra); Palle, Komaraiah.

    In: Biochimica et Biophysica Acta - Molecular Basis of Disease, 01.01.2019.

    Research output: Contribution to journalReview article

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