DNA of 21 clinical cytomegalovirus strains detected by hybridization to cloned DNA fragments of laboratory strain AD‐169

Sunwen Chou, Linda Roark, Thomas C. Merigan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Nine distinct DNA probes prepared from cloned DNA fragments of the cytomegalovirus (CMV) strain AD‐169, each representing a relatively small portion of the total genome, were able to detect all 21 epidemiologically distinct clinical isolates of CMV that had been passaged in tissue culture. All probes were of comparable sensitivity in the detection of CMV, and under the hybridization conditions used, no probe gave an unusually high background with uninfected host cells.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalJournal of Medical Virology
Volume14
Issue number3
DOIs
StatePublished - 1984

Keywords

  • cytomegalovirus
  • hybridization
  • viral DNA

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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