Dna damage in uvb-irradiated keratinocytes

Alexander E. Maccubbin, Joseph Przybyszewski, Marianne S. Evans, Edwin E. Budzinski, Helen B. Patrzyc, M. Kulesz-martin, Harold C. Box

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by 32P-postlabeling and electrochemical detection methods respectively.

Original languageEnglish (US)
Pages (from-to)1659-1660
Number of pages2
JournalCarcinogenesis
Volume16
Issue number7
DOIs
StatePublished - Jul 1 1995

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Dna damage in uvb-irradiated keratinocytes'. Together they form a unique fingerprint.

  • Cite this

    Maccubbin, A. E., Przybyszewski, J., Evans, M. S., Budzinski, E. E., Patrzyc, H. B., Kulesz-martin, M., & Box, H. C. (1995). Dna damage in uvb-irradiated keratinocytes. Carcinogenesis, 16(7), 1659-1660. https://doi.org/10.1093/carcin/16.7.1659