Dna damage in uvb-irradiated keratinocytes

Alexander E. Maccubbin; Joseph Przybyszewski; Marianne S. Evans; Edwin E. Budzinski; Helen B. Patrzyc; M. Kulesz-martin; Harold C. Box

doi:10.1093/carcin/16.7.1659

Dna damage in uvb-irradiated keratinocytes

Alexander E. Maccubbin, Joseph Przybyszewski, Marianne S. Evans, Edwin E. Budzinski, Helen B. Patrzyc, M. Kulesz-martin, Harold C. Box

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by ³²P-postlabeling and electrochemical detection methods respectively.

Original language	English (US)
Pages (from-to)	1659-1660
Number of pages	2
Journal	Carcinogenesis
Volume	16
Issue number	7
DOIs	https://doi.org/10.1093/carcin/16.7.1659
State	Published - Jul 1995
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

Access to Document

10.1093/carcin/16.7.1659

Cite this

@article{fbc4a95c6cde413ab297528be64781d1,

title = "Dna damage in uvb-irradiated keratinocytes",

abstract = "A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by 32P-postlabeling and electrochemical detection methods respectively.",

author = "Maccubbin, {Alexander E.} and Joseph Przybyszewski and Evans, {Marianne S.} and Budzinski, {Edwin E.} and Patrzyc, {Helen B.} and M. Kulesz-martin and Box, {Harold C.}",

note = "Funding Information: The expertise and co-operation of Dr Thomas Nicoteia is gratelullv acknowledged Support from the National Cancer Institute, grants CA 46838 and CA 25027. is gratelullv acknowledged",

year = "1995",

month = jul,

doi = "10.1093/carcin/16.7.1659",

language = "English (US)",

volume = "16",

pages = "1659--1660",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Dna damage in uvb-irradiated keratinocytes

AU - Maccubbin, Alexander E.

AU - Przybyszewski, Joseph

AU - Evans, Marianne S.

AU - Budzinski, Edwin E.

AU - Patrzyc, Helen B.

AU - Kulesz-martin, M.

AU - Box, Harold C.

N1 - Funding Information: The expertise and co-operation of Dr Thomas Nicoteia is gratelullv acknowledged Support from the National Cancer Institute, grants CA 46838 and CA 25027. is gratelullv acknowledged

PY - 1995/7

Y1 - 1995/7

N2 - A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by 32P-postlabeling and electrochemical detection methods respectively.

AB - A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by 32P-postlabeling and electrochemical detection methods respectively.

UR - http://www.scopus.com/inward/record.url?scp=0028998606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028998606&partnerID=8YFLogxK

U2 - 10.1093/carcin/16.7.1659

DO - 10.1093/carcin/16.7.1659

M3 - Article

C2 - 7614703

AN - SCOPUS:0028998606

SN - 0143-3334

VL - 16

SP - 1659

EP - 1660

JO - Carcinogenesis

JF - Carcinogenesis

IS - 7

ER -

Dna damage in uvb-irradiated keratinocytes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this