Dna damage in uvb-irradiated keratinocytes

Alexander E. Maccubbin, Joseph Przybyszewski, Marianne S. Evans, Edwin E. Budzinski, Helen B. Patrzyc, Molly Kulesz-Martin, Harold C. Box

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A DNA lesion which results from the breakdown of a pyrimidine base leaving a formamido remnant has been associated with oxidative stress. This lesion is shown to be produced in keratinocytes irradiated in culture with UVB light. The amount of formamido lesion produced is comparable to the amount of the 8-hydroxyguanine lesion. The two lesions were measured by 32P-postlabeling and electrochemical detection methods respectively.

Original languageEnglish (US)
Pages (from-to)1659-1660
Number of pages2
JournalCarcinogenesis
Volume16
Issue number7
DOIs
StatePublished - Jul 1995
Externally publishedYes

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Oxidative Stress
Oxidative stress
Keratinocytes
Breakdown
DNA
Damage
Light
pyrimidine
8-hydroxyguanine
Culture

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Maccubbin, A. E., Przybyszewski, J., Evans, M. S., Budzinski, E. E., Patrzyc, H. B., Kulesz-Martin, M., & Box, H. C. (1995). Dna damage in uvb-irradiated keratinocytes. Carcinogenesis, 16(7), 1659-1660. https://doi.org/10.1093/carcin/16.7.1659

Dna damage in uvb-irradiated keratinocytes. / Maccubbin, Alexander E.; Przybyszewski, Joseph; Evans, Marianne S.; Budzinski, Edwin E.; Patrzyc, Helen B.; Kulesz-Martin, Molly; Box, Harold C.

In: Carcinogenesis, Vol. 16, No. 7, 07.1995, p. 1659-1660.

Research output: Contribution to journalArticle

Maccubbin, AE, Przybyszewski, J, Evans, MS, Budzinski, EE, Patrzyc, HB, Kulesz-Martin, M & Box, HC 1995, 'Dna damage in uvb-irradiated keratinocytes', Carcinogenesis, vol. 16, no. 7, pp. 1659-1660. https://doi.org/10.1093/carcin/16.7.1659
Maccubbin AE, Przybyszewski J, Evans MS, Budzinski EE, Patrzyc HB, Kulesz-Martin M et al. Dna damage in uvb-irradiated keratinocytes. Carcinogenesis. 1995 Jul;16(7):1659-1660. https://doi.org/10.1093/carcin/16.7.1659
Maccubbin, Alexander E. ; Przybyszewski, Joseph ; Evans, Marianne S. ; Budzinski, Edwin E. ; Patrzyc, Helen B. ; Kulesz-Martin, Molly ; Box, Harold C. / Dna damage in uvb-irradiated keratinocytes. In: Carcinogenesis. 1995 ; Vol. 16, No. 7. pp. 1659-1660.
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