Abstract
Here we define the expression of ≈ 100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 b-HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 556-572 |
| Number of pages | 17 |
| Journal | Journal of Comparative Neurology |
| Volume | 512 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 1 2009 |
| Externally published | Yes |
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Keywords
- Basal ganglia
- Dlx
- Forebrain
- GABA
- Mash
- Mouse
- Neuron
ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
Cite this
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. / Long, Jason E.; Swan, Christo; Liang, Winnie S.; Cobos, Inma; Potter, Gregory; Rubenstein, John L R.
In: Journal of Comparative Neurology, Vol. 512, No. 4, 01.02.2009, p. 556-572.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
AU - Long, Jason E.
AU - Swan, Christo
AU - Liang, Winnie S.
AU - Cobos, Inma
AU - Potter, Gregory
AU - Rubenstein, John L R
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Here we define the expression of ≈ 100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 b-HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum.
AB - Here we define the expression of ≈ 100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 b-HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum.
KW - Basal ganglia
KW - Dlx
KW - Forebrain
KW - GABA
KW - Mash
KW - Mouse
KW - Neuron
UR - http://www.scopus.com/inward/record.url?scp=59049084200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59049084200&partnerID=8YFLogxK
U2 - 10.1002/cne.21854
DO - 10.1002/cne.21854
M3 - Article
C2 - 19030180
AN - SCOPUS:59049084200
VL - 512
SP - 556
EP - 572
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
SN - 0021-9967
IS - 4
ER -