Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways

Jason E. Long, Inma Cobos, Greg B. Potter, John L.R. Rubenstein

    Research output: Contribution to journalArticle

    100 Scopus citations

    Abstract

    Here we define the expression of -100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most γ-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlxindependent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.

    Original languageEnglish (US)
    Pages (from-to)i96-i106
    JournalCerebral Cortex
    Volume19
    Issue numberSUPPL. 1
    DOIs
    StatePublished - Jul 1 2009

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    Keywords

    • CGE
    • Dlx
    • MGE
    • Mash
    • Transcription factor

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Cellular and Molecular Neuroscience

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