Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways

Jason E. Long, Inma Cobos, Gregory Potter, John L R Rubenstein

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Here we define the expression of -100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most γ-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlxindependent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.

Original languageEnglish (US)
JournalCerebral Cortex
Volume19
Issue numberSUPPL. 1
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Interneurons
Basal Ganglia
Transcription Factors
Basic Helix-Loop-Helix Transcription Factors
Neurons
Telencephalon
Globus Pallidus
Essential Genes
Genes

Keywords

  • CGE
  • Dlx
  • Mash
  • MGE
  • Transcription factor

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. / Long, Jason E.; Cobos, Inma; Potter, Gregory; Rubenstein, John L R.

In: Cerebral Cortex, Vol. 19, No. SUPPL. 1, 07.2009.

Research output: Contribution to journalArticle

Long, Jason E. ; Cobos, Inma ; Potter, Gregory ; Rubenstein, John L R. / Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. In: Cerebral Cortex. 2009 ; Vol. 19, No. SUPPL. 1.
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