Divergent plasticity of prefrontal cortex networks

Bita Moghaddam, Houman Homayoun

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

The 'executive' regions of the prefrontal cortex (PFC) such as the dorsolateral PFC (dlPFC) and its rodent equivalent medial PFC (mPFC) are thought to respond in concert with the 'limbic' regions of the PFC such as the orbitofrontal (OFC) cortex to orchestrate behavior that is consistent with context and expected outcome. Both groups of regions have been implicated in behavioral abnormalities associated with addiction and psychiatric disorders, in particular, schizophrenia and mood disorders. Theories about the pathophysiology of these disorders, however, incorporate abnormalities in discrete PFC regions independently of each other or assume they are one and the same and, thus, bunch them under umbrella of 'PFC dysfunction.' Emerging data from animal studies suggest that mPFC and OFC neurons display opposing patterns of plasticity during associative learning and in response to repeated exposure to psychostimulants. These data corroborate clinical studies reporting different patterns of activation in OFC versus dlPFC in individuals with schizophrenia or addictive disorders. These suggest that concomitant but divergent engagement of discrete PFC regions is critical for learning stimulus-outcome associations, and the execution of goal-directed behavior that is based on these associations. An atypical interplay between these regions may lead to abnormally high or low salience assigned to stimuli, resulting in symptoms that are fundamental to many psychiatric and addictive disorders, including attentional deficits, improper affective response to stimuli, and inflexible or impulsive behavior.

Original languageEnglish (US)
Pages (from-to)42-55
Number of pages14
JournalNeuropsychopharmacology
Volume33
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Prefrontal Cortex
Psychiatry
Schizophrenia
Learning
Impulsive Behavior
Mood Disorders
Rodentia
Neurons

Keywords

  • Electrophysiology
  • Learning
  • Orbitofrontal cortex
  • Schizophrenia
  • Substance abuse
  • Working memory

ASJC Scopus subject areas

  • Pharmacology

Cite this

Divergent plasticity of prefrontal cortex networks. / Moghaddam, Bita; Homayoun, Houman.

In: Neuropsychopharmacology, Vol. 33, No. 1, 01.2008, p. 42-55.

Research output: Contribution to journalReview article

Moghaddam, Bita ; Homayoun, Houman. / Divergent plasticity of prefrontal cortex networks. In: Neuropsychopharmacology. 2008 ; Vol. 33, No. 1. pp. 42-55.
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