Diuretics and salt transport along the nephron

Paul L. Bernstein, David Ellison

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The clinical use of diuretics almost uniformly predated the localization of their site of action. The consequence of diuretic specificity predicts clinical application and side effect, and the proximity of the sodium transporters, one to the next, often dictates potency or diuretic efficiency. All diuretics function by inhibiting the normal transport of sodium from the filtrate into the renal tubular cells. This movement of sodium into the renal epithelial cells on the apical side is facilitated by a series of transporters whose function is, in turn, dependent on the adenosine triphosphate (ATP)-dependent Na-K cotransporter on the basolateral side of the cell. Our growing understanding of the physiology of sodium transport has spawned new possibilities for diuretic development.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalSeminars in Nephrology
Volume31
Issue number6
DOIs
StatePublished - Nov 2011

Fingerprint

Nephrons
Diuretics
Salts
Sodium
Kidney
Adenosine Triphosphate
Epithelial Cells

Keywords

  • Cortical collecting tubule
  • Distal convoluted tubule
  • Diuretics
  • Loop of Henle
  • Proximal tubule
  • Sodium transport

ASJC Scopus subject areas

  • Nephrology

Cite this

Diuretics and salt transport along the nephron. / Bernstein, Paul L.; Ellison, David.

In: Seminars in Nephrology, Vol. 31, No. 6, 11.2011, p. 475-482.

Research output: Contribution to journalArticle

Bernstein, Paul L. ; Ellison, David. / Diuretics and salt transport along the nephron. In: Seminars in Nephrology. 2011 ; Vol. 31, No. 6. pp. 475-482.
@article{d77d1c27ac3745789e84336d7bd030e3,
title = "Diuretics and salt transport along the nephron",
abstract = "The clinical use of diuretics almost uniformly predated the localization of their site of action. The consequence of diuretic specificity predicts clinical application and side effect, and the proximity of the sodium transporters, one to the next, often dictates potency or diuretic efficiency. All diuretics function by inhibiting the normal transport of sodium from the filtrate into the renal tubular cells. This movement of sodium into the renal epithelial cells on the apical side is facilitated by a series of transporters whose function is, in turn, dependent on the adenosine triphosphate (ATP)-dependent Na-K cotransporter on the basolateral side of the cell. Our growing understanding of the physiology of sodium transport has spawned new possibilities for diuretic development.",
keywords = "Cortical collecting tubule, Distal convoluted tubule, Diuretics, Loop of Henle, Proximal tubule, Sodium transport",
author = "Bernstein, {Paul L.} and David Ellison",
year = "2011",
month = "11",
doi = "10.1016/j.semnephrol.2011.09.002",
language = "English (US)",
volume = "31",
pages = "475--482",
journal = "Seminars in Nephrology",
issn = "0270-9295",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Diuretics and salt transport along the nephron

AU - Bernstein, Paul L.

AU - Ellison, David

PY - 2011/11

Y1 - 2011/11

N2 - The clinical use of diuretics almost uniformly predated the localization of their site of action. The consequence of diuretic specificity predicts clinical application and side effect, and the proximity of the sodium transporters, one to the next, often dictates potency or diuretic efficiency. All diuretics function by inhibiting the normal transport of sodium from the filtrate into the renal tubular cells. This movement of sodium into the renal epithelial cells on the apical side is facilitated by a series of transporters whose function is, in turn, dependent on the adenosine triphosphate (ATP)-dependent Na-K cotransporter on the basolateral side of the cell. Our growing understanding of the physiology of sodium transport has spawned new possibilities for diuretic development.

AB - The clinical use of diuretics almost uniformly predated the localization of their site of action. The consequence of diuretic specificity predicts clinical application and side effect, and the proximity of the sodium transporters, one to the next, often dictates potency or diuretic efficiency. All diuretics function by inhibiting the normal transport of sodium from the filtrate into the renal tubular cells. This movement of sodium into the renal epithelial cells on the apical side is facilitated by a series of transporters whose function is, in turn, dependent on the adenosine triphosphate (ATP)-dependent Na-K cotransporter on the basolateral side of the cell. Our growing understanding of the physiology of sodium transport has spawned new possibilities for diuretic development.

KW - Cortical collecting tubule

KW - Distal convoluted tubule

KW - Diuretics

KW - Loop of Henle

KW - Proximal tubule

KW - Sodium transport

UR - http://www.scopus.com/inward/record.url?scp=81355164040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81355164040&partnerID=8YFLogxK

U2 - 10.1016/j.semnephrol.2011.09.002

DO - 10.1016/j.semnephrol.2011.09.002

M3 - Article

C2 - 22099504

AN - SCOPUS:81355164040

VL - 31

SP - 475

EP - 482

JO - Seminars in Nephrology

JF - Seminars in Nephrology

SN - 0270-9295

IS - 6

ER -