Diuretic combinations in the treatment of edema: Rationale and recommendations

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Most patients with edematous disorders such as congestive heart failure, nephrotic syndrome, and cirrhotic ascites can be treated successfully with dietary NaCl restrictum and a single class of diuretic drug. For resistant patients, it may be necessary to combine two different classes of diuretic drug to control symptoms. Recent experimental work has shown that specific renal adaptations contribute to diuretic resistance by increasing the capacity of the kidney to reabsorb NaCl. Combination diuretic therapy can be used to overcome these processes, but its indiscriminate use can also lead to serious complications. A rational approach to diuretic-resistant patients is based on understanding how adaptive renal responses can be heated and prevented using targeted diuretic therapy. Such an approach provides the most effective diuresis without undue complications.

Original languageEnglish (US)
JournalDrug Therapy
Volume24
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Diuretics
Edema
Kidney
Therapeutics
Drug and Narcotic Control
Diuresis
Nephrotic Syndrome
Ascites
Heart Failure
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Diuretic combinations in the treatment of edema : Rationale and recommendations. / Ellison, David.

In: Drug Therapy, Vol. 24, No. 3, 1994.

Research output: Contribution to journalArticle

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