Diuretic action of the narcotic antagonist oxilorphan

John Nutt, Donald R. Jasinski

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The narcotic antagonists oxilorphan and d,l-cyclazocine increased urinary output without affecting fluid intake in 10 subjects on ad libitum fluids. In 8 water-deprived subjects oxilorphan increased urinary output and decreased urine osmolality without significantly altering blood pressure, creatinine clearance, electrolyte excretion, or solute excretion. Three of 4 water-loaded subjects excreted a water load slightly more efficiently after the drug. Ten milligrams o f naloxone had no diuretic effect itself and did not antagonize the diuretic effect o f oxilorphan. Five units o f vasopressin prevented the drug-induced diuresis. These results suggest that the diuretic effect is an agonistic action of oxilorphan produced by inhibition of antidiuretic hormone (ADH) release.

Original languageEnglish (US)
Pages (from-to)361-367
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume15
Issue number4
StatePublished - Apr 1974
Externally publishedYes

Fingerprint

Narcotic Antagonists
Diuretics
Vasopressins
Water
Cyclazocine
Diuresis
Naloxone
Pharmaceutical Preparations
Osmolar Concentration
Electrolytes
Creatinine
Urine
Blood Pressure
oxilorphan

ASJC Scopus subject areas

  • Pharmacology

Cite this

Diuretic action of the narcotic antagonist oxilorphan. / Nutt, John; Jasinski, Donald R.

In: Clinical Pharmacology and Therapeutics, Vol. 15, No. 4, 04.1974, p. 361-367.

Research output: Contribution to journalArticle

Nutt, John ; Jasinski, Donald R. / Diuretic action of the narcotic antagonist oxilorphan. In: Clinical Pharmacology and Therapeutics. 1974 ; Vol. 15, No. 4. pp. 361-367.
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