Distribution of Substance P Neurons in the Epithalamus of the Rat: An Immunohistochemical Investigation

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Abstract

Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase‐antiperoxidase immunocytochemical technique. Cells containing immunoreactive SP were located in the medial habenula, and SP fibers were observed in the lateral habenula, habenular commissure, pineal stalk, and the pineal organ. Bilateral removal of the superior cervical ganglia did not affect the immunocytochemical staining of SP‐containing cells and fibers 15–30 days later. It is suggested that habenular neurons containing SP send projections into the pineal organ of the rat.

Original languageEnglish (US)
Pages (from-to)355-370
Number of pages16
JournalJournal of pineal research
Volume1
Issue number4
DOIs
StatePublished - Oct 1984

Keywords

  • habenula
  • pineal organ
  • substance P
  • superior cervical ganglionectomy

ASJC Scopus subject areas

  • Endocrinology

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