Distribution of substance P neurons in the epithalamus of the rat: An immunohistochemical investigation

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Abstract

Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase-antiperoxidase immunocytochemical technique. Cells containing immunoreactive SP were located in the medial habenula, and SP fibers were observed in the lateral habenula, habenular commissure, pineal stalk, and the pineal organ. Bilateral removal of the superior cervical ganglia did not affect the immunocytochemical staining of SP-containing cells and fibers 15-30 days later. It is suggested that habenular neurons containing SP send projections into the pineal organ of the rat.

Original languageEnglish (US)
Pages (from-to)355-370
Number of pages16
JournalJournal of Pineal Research
Volume1
Issue number4
StatePublished - 1984

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Epithalamus
Substance P
Habenula
Neurons
Superior Cervical Ganglion
Peroxidase
Staining and Labeling

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase-antiperoxidase immunocytochemical technique. Cells containing immunoreactive SP were located in the medial habenula, and SP fibers were observed in the lateral habenula, habenular commissure, pineal stalk, and the pineal organ. Bilateral removal of the superior cervical ganglia did not affect the immunocytochemical staining of SP-containing cells and fibers 15-30 days later. It is suggested that habenular neurons containing SP send projections into the pineal organ of the rat.",
author = "Oline Ronnekleiv and Martin Kelly",
year = "1984",
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AU - Ronnekleiv, Oline

AU - Kelly, Martin

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AB - Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase-antiperoxidase immunocytochemical technique. Cells containing immunoreactive SP were located in the medial habenula, and SP fibers were observed in the lateral habenula, habenular commissure, pineal stalk, and the pineal organ. Bilateral removal of the superior cervical ganglia did not affect the immunocytochemical staining of SP-containing cells and fibers 15-30 days later. It is suggested that habenular neurons containing SP send projections into the pineal organ of the rat.

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