Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain

Expression in areas associated with learning and memory

Zhengui Xia, Cheryl D. Refsdal, Kalpana M. Merchant, Daniel Dorsa, Daniel R. Storm

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

The Drosophila learning mutant, rutabaga, is deficient in the calmodulin-sensitive adenylate cyclase, and studies of associative learning in Aplysia have implicated this enzyme in neuroplasticity. Therefore, the distribution of mRNA encoding the calmodulin-sensitive adenylate cyclase in rat brain was examined by in situ hybridization. mRNA for this enzyme is expressed in specific areas of brain that have been implicated in learning and memory, including the neocortex, the hippocampus, and the olfactory system. The presence of mRNA for this enzyme in the pyramidal and granule cells of the hippocampal formation provides evidence that it is found in neurons. These data are consistent with the proposal that the calmodulin-sensitive adenylate cyclase plays an important role in learning and memory.

Original languageEnglish (US)
Pages (from-to)431-443
Number of pages13
JournalNeuron
Volume6
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

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Calmodulin
Adenylyl Cyclases
Learning
Messenger RNA
Brain
Hippocampus
Enzymes
Aplysia
Brassica napus
Neuronal Plasticity
Pyramidal Cells
Neocortex
Drosophila
In Situ Hybridization
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain : Expression in areas associated with learning and memory. / Xia, Zhengui; Refsdal, Cheryl D.; Merchant, Kalpana M.; Dorsa, Daniel; Storm, Daniel R.

In: Neuron, Vol. 6, No. 3, 1991, p. 431-443.

Research output: Contribution to journalArticle

Xia, Zhengui ; Refsdal, Cheryl D. ; Merchant, Kalpana M. ; Dorsa, Daniel ; Storm, Daniel R. / Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain : Expression in areas associated with learning and memory. In: Neuron. 1991 ; Vol. 6, No. 3. pp. 431-443.
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