Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

The large number of metabotropic glutamate receptor subtypes suggests diverse roles in brain function, although specific distribution patterns can give clues to subtype-specific functions [Hayashi Y. et al. (1993) Nature366, 687-690; Nakajima Y. et al. (1993) J. biol. Chem.268, 11868-11873; Nomura A. et al. (1994) Cell77, 361-369; Ohishi H. et al. (1993) Neuroscience53, 1009-1018]. The metabotropic glutamate receptor mGluR7 is sensitive to the agonistl-2-amino-4-phosphonobutyric acid, a presynaptic inhibitor of neurotransmitter release. We examined the anatomic distribution of mGluR7 messenger RNA expression by in situ hybridization in the developing and adult rat central nervous system. Our results demonstrate that mGluR7 messenger RNA is among the most widely distributed of metabotropic glutamate receptors in both the developing and adult rat nervous system and that mGluR7 messenger RNA is expressed in most neuronal groups known to respond tol-2-amino-4-phosphonobutyric acid, including mitral cells of the olfactory bulb, granule cells of the dentate gyrus and neurons of the entorhinal cortex and dorsal root ganglion. mGluR7 exhibits preferential expression in sensory afferent pathways and is highly represented in the periventricular zone of the hypothalamus, the latter implying a modulatory role for mGluR7 in neuroendocrine pathways. Most strikingly, the majority of neurons at all levels of olfactory circuitry are among the areas of highest mGluR7 messenger RNA content. The anatomic distribution of mGluR7 messenger RNA suggests that mGluR7 activation may participate in the processing of hippocampal, sensory and olfactory information.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalNeuroscience
Volume69
Issue number1
DOIs
StatePublished - 1995

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Messenger RNA
Brain
Metabotropic Glutamate Receptors
Afferent Pathways
metabotropic glutamate receptor 7
Neurons
Entorhinal Cortex
Olfactory Bulb
Dentate Gyrus
Spinal Ganglia
Nervous System
Hypothalamus
In Situ Hybridization
Neurotransmitter Agents
Central Nervous System
2-amino-4-phosphonobutyric acid

Keywords

  • 2-amino-4-phosphonobutyric acid
  • AP4
  • dithiothreitol
  • DTT
  • E
  • EDTA
  • embryonic day
  • ethylenediaminetetra-acetate
  • hypothalamus
  • in situ hybridization
  • l-2-amino-4-phosphonobutyric acid
  • lateral olfactory tract
  • LC
  • locus coeruleus
  • LOT
  • metabotropic glutamate receptor
  • mGluR
  • olfactory
  • P
  • PO
  • postnatal day
  • presynaptic
  • primary olfactory cortex
  • spinal cord
  • SSC
  • standard saline citrate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain. / Kinzie, John (Mark); Saugstad, Julie; Westbrook, Gary; Segerson, T. P.

In: Neuroscience, Vol. 69, No. 1, 1995, p. 167-176.

Research output: Contribution to journalArticle

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AU - Saugstad, Julie

AU - Westbrook, Gary

AU - Segerson, T. P.

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N2 - The large number of metabotropic glutamate receptor subtypes suggests diverse roles in brain function, although specific distribution patterns can give clues to subtype-specific functions [Hayashi Y. et al. (1993) Nature366, 687-690; Nakajima Y. et al. (1993) J. biol. Chem.268, 11868-11873; Nomura A. et al. (1994) Cell77, 361-369; Ohishi H. et al. (1993) Neuroscience53, 1009-1018]. The metabotropic glutamate receptor mGluR7 is sensitive to the agonistl-2-amino-4-phosphonobutyric acid, a presynaptic inhibitor of neurotransmitter release. We examined the anatomic distribution of mGluR7 messenger RNA expression by in situ hybridization in the developing and adult rat central nervous system. Our results demonstrate that mGluR7 messenger RNA is among the most widely distributed of metabotropic glutamate receptors in both the developing and adult rat nervous system and that mGluR7 messenger RNA is expressed in most neuronal groups known to respond tol-2-amino-4-phosphonobutyric acid, including mitral cells of the olfactory bulb, granule cells of the dentate gyrus and neurons of the entorhinal cortex and dorsal root ganglion. mGluR7 exhibits preferential expression in sensory afferent pathways and is highly represented in the periventricular zone of the hypothalamus, the latter implying a modulatory role for mGluR7 in neuroendocrine pathways. Most strikingly, the majority of neurons at all levels of olfactory circuitry are among the areas of highest mGluR7 messenger RNA content. The anatomic distribution of mGluR7 messenger RNA suggests that mGluR7 activation may participate in the processing of hippocampal, sensory and olfactory information.

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