Abstract
Salts of sulfate, lithium, and bromine were injected or infused intravenously into ewes in the last trimester of gestation. Ewes and fetuses had indwelling catheters, most fetuses were nephrectomized. Concentrations were measured in paired maternal and fetal samples over periods of 4-14 days. Maternal excretion of sulfate was too rapid to permit near equilibration of fetal and maternal plasma concentrations; the results, however, did not support the existence of a large potential difference across the exchange barrier. The concentrations of Li+ (given by continuous infusion) and 82Br- in maternal plasma did not change rapidly. The concentrations of these tracers in fetal plasma rose until they were nearly equal to the maternal plasma concentrations. Steady-state transplacental potentials, calculated by use of the Nernst equation, were 5.2 ± 2.0 (SEM) mV (n = 26) for Li+ and -2.2 ± 0.8 (SEM) mV (n = 10) for Br-. Nernst potentials calculated from previously measured maternal and fetal plasma concentrations of Na+, K+, Mg2+, and Cl- were +0.4, +3.6, +0.5, and -1.4 mV. The authors concluded that, of the total potential difference of about -50 mV (fetus negative) between the fetal lamb and the ewe, only a few mV are dropped across the placental exchange barrier.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 5 |
| Issue number | 1 |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry
- Physiology
Cite this
Distribution of ionic sulfate, lithium, and bromide across the sheep placenta. / Thornburg, Kent; Binder, N. D.; Faber, J. J.
In: American Journal of Physiology - Cell Physiology, Vol. 5, No. 1, 1979.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution of ionic sulfate, lithium, and bromide across the sheep placenta
AU - Thornburg, Kent
AU - Binder, N. D.
AU - Faber, J. J.
PY - 1979
Y1 - 1979
N2 - Salts of sulfate, lithium, and bromine were injected or infused intravenously into ewes in the last trimester of gestation. Ewes and fetuses had indwelling catheters, most fetuses were nephrectomized. Concentrations were measured in paired maternal and fetal samples over periods of 4-14 days. Maternal excretion of sulfate was too rapid to permit near equilibration of fetal and maternal plasma concentrations; the results, however, did not support the existence of a large potential difference across the exchange barrier. The concentrations of Li+ (given by continuous infusion) and 82Br- in maternal plasma did not change rapidly. The concentrations of these tracers in fetal plasma rose until they were nearly equal to the maternal plasma concentrations. Steady-state transplacental potentials, calculated by use of the Nernst equation, were 5.2 ± 2.0 (SEM) mV (n = 26) for Li+ and -2.2 ± 0.8 (SEM) mV (n = 10) for Br-. Nernst potentials calculated from previously measured maternal and fetal plasma concentrations of Na+, K+, Mg2+, and Cl- were +0.4, +3.6, +0.5, and -1.4 mV. The authors concluded that, of the total potential difference of about -50 mV (fetus negative) between the fetal lamb and the ewe, only a few mV are dropped across the placental exchange barrier.
AB - Salts of sulfate, lithium, and bromine were injected or infused intravenously into ewes in the last trimester of gestation. Ewes and fetuses had indwelling catheters, most fetuses were nephrectomized. Concentrations were measured in paired maternal and fetal samples over periods of 4-14 days. Maternal excretion of sulfate was too rapid to permit near equilibration of fetal and maternal plasma concentrations; the results, however, did not support the existence of a large potential difference across the exchange barrier. The concentrations of Li+ (given by continuous infusion) and 82Br- in maternal plasma did not change rapidly. The concentrations of these tracers in fetal plasma rose until they were nearly equal to the maternal plasma concentrations. Steady-state transplacental potentials, calculated by use of the Nernst equation, were 5.2 ± 2.0 (SEM) mV (n = 26) for Li+ and -2.2 ± 0.8 (SEM) mV (n = 10) for Br-. Nernst potentials calculated from previously measured maternal and fetal plasma concentrations of Na+, K+, Mg2+, and Cl- were +0.4, +3.6, +0.5, and -1.4 mV. The authors concluded that, of the total potential difference of about -50 mV (fetus negative) between the fetal lamb and the ewe, only a few mV are dropped across the placental exchange barrier.
UR - http://www.scopus.com/inward/record.url?scp=0018344928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018344928&partnerID=8YFLogxK
M3 - Article
C2 - 434139
AN - SCOPUS:0018344928
VL - 5
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 1
ER -