Distribution of D5 dopamine receptor mRNA in rat brain

James H. Meador-Woodruff, Alfred Mansour, David K. Grandy, Scott P. Damask, Olivier Civelli, Stanley J. Watson

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

The distribution of the messenger RNA encoding the dopamine D5 receptor was determined in the rat brain by in situ hybridization. Using [35S]-labelled riboprobes to either the rat or human D5 receptor, this mRNA was localized to the hippocampus and the parafascicular nucleus of the thalamus. This mRNA could not be visualized in the more traditional brain regions associated with dopaminergic cell bodies or projection fields. This unusual distribution suggests a novel function in the brain for this subtype of the dopamine receptor.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalNeuroscience Letters
Volume145
Issue number2
DOIs
StatePublished - Oct 12 1992
Externally publishedYes

Keywords

  • Catecholamine
  • Dopamine
  • Messenger
  • RNA
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Distribution of D<sub>5</sub> dopamine receptor mRNA in rat brain'. Together they form a unique fingerprint.

Cite this