Distribution of D5 dopamine receptor mRNA in rat brain

James H. Meador-Woodruff, Alfred Mansour, David K. Grandy, Scott P. Damask, Olivier Civelli, Stanley J. Watson

    Research output: Contribution to journalArticle

    132 Scopus citations

    Abstract

    The distribution of the messenger RNA encoding the dopamine D5 receptor was determined in the rat brain by in situ hybridization. Using [35S]-labelled riboprobes to either the rat or human D5 receptor, this mRNA was localized to the hippocampus and the parafascicular nucleus of the thalamus. This mRNA could not be visualized in the more traditional brain regions associated with dopaminergic cell bodies or projection fields. This unusual distribution suggests a novel function in the brain for this subtype of the dopamine receptor.

    Original languageEnglish (US)
    Pages (from-to)209-212
    Number of pages4
    JournalNeuroscience Letters
    Volume145
    Issue number2
    DOIs
    StatePublished - Oct 12 1992

    Keywords

    • Catecholamine
    • Dopamine
    • Messenger
    • RNA
    • Receptor

    ASJC Scopus subject areas

    • Neuroscience(all)

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  • Cite this

    Meador-Woodruff, J. H., Mansour, A., Grandy, D. K., Damask, S. P., Civelli, O., & Watson, S. J. (1992). Distribution of D5 dopamine receptor mRNA in rat brain. Neuroscience Letters, 145(2), 209-212. https://doi.org/10.1016/0304-3940(92)90024-2