Original language | English (US) |
---|---|
Pages (from-to) | 245-246 |
Number of pages | 2 |
Journal | Regulatory Peptides |
Volume | 54 |
Issue number | 1 |
DOIs | |
State | Published - Nov 10 1994 |
ASJC Scopus subject areas
- Physiology
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Cellular and Molecular Neuroscience
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In: Regulatory Peptides, Vol. 54, No. 1, 10.11.1994, p. 245-246.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Distribution of μ-opioid receptor mRNA in female rat brain
AU - Rönnekleiv, OK
AU - Bosch, MA
AU - Zhang, G.
AU - Bunzow, JR
AU - Grandy, DK
AU - Kelly, MJ
N1 - Funding Information: mRNA (5), revealed that IJ-opioid receptor mRNA was present within oxytocin-containing cells. At the level of the basal hypothalamus, p-receptor mRNA was expressed in the arcuate, dorsomedial, posterior, and premammillary nuclei. The most extensive signal of IJ -receptor mRNA expression was observed in various nuclei of the thalamus and the medial habenula. Thus, in the anterior part of the thalamus, a high level of expression was seen in the paraventricular nucleus thalamus, parataenial, reuniens and the anteroventral nucleus. Further caudal, relative high level of expression was observed in the majority of thalamic nuclei, including the medial and lateral geniculate, subparafascicular and ventral posteriomedial nuclei. In the hippocampus labeled cells were observed in the pyramidal cell layer of CA1, CA2 and CA3 and scattered cells were also found in the granule cell layer of the dentate gyrus. In the amygdala the highest level of labeling was observed in the medial, central and basolateral nuclei. These studies indicate that IJ-opioid receptor mRNA shows widespread distribution in the rostral forebrain of ovariectomized female rats. Within the POA IJ -receptor mRNA was expressed in areas such as the OVLT, AVPV and MPN, that are important for the control of GnRH and LH secretion. Within the basal hypothalamus tJ -receptor mRNA was expressed in different nuclei including the arcuate, which supports electrophysiological findings of IJ-opioid actions (2). Experiments are in progress to further elucidate the cellular phenotypes that express p-receptor mRNA and the ovarian steroid regulation of the preceptor mRNA (6). (Supported by PHS grants HD16793, DA05158, DA08562)
PY - 1994/11/10
Y1 - 1994/11/10
UR - http://www.scopus.com/inward/record.url?scp=0028046840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028046840&partnerID=8YFLogxK
U2 - 10.1016/0167-0115(94)90481-2
DO - 10.1016/0167-0115(94)90481-2
M3 - Article
AN - SCOPUS:0028046840
SN - 0167-0115
VL - 54
SP - 245
EP - 246
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 1
ER -