Distribution of μ-opioid receptor mRNA in female rat brain

OK Rönnekleiv; MA Bosch; G. Zhang; JR Bunzow; DK Grandy; MJ Kelly

doi:10.1016/0167-0115(94)90481-2

Distribution of μ-opioid receptor mRNA in female rat brain

OK Rönnekleiv, MA Bosch, G. Zhang, JR Bunzow, DK Grandy, MJ Kelly

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	245-246
Number of pages	2
Journal	Regulatory Peptides
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/0167-0115(94)90481-2
State	Published - Nov 10 1994

ASJC Scopus subject areas

Physiology
Biochemistry
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/0167-0115(94)90481-2

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@article{924d3fa0267644daad19c37b2fdd47d5,

title = "Distribution of μ-opioid receptor mRNA in female rat brain",

author = "OK R{\"o}nnekleiv and MA Bosch and G. Zhang and JR Bunzow and DK Grandy and MJ Kelly",

note = "Funding Information: mRNA (5), revealed that IJ-opioid receptor mRNA was present within oxytocin-containing cells. At the level of the basal hypothalamus, p-receptor mRNA was expressed in the arcuate, dorsomedial, posterior, and premammillary nuclei. The most extensive signal of IJ -receptor mRNA expression was observed in various nuclei of the thalamus and the medial habenula. Thus, in the anterior part of the thalamus, a high level of expression was seen in the paraventricular nucleus thalamus, parataenial, reuniens and the anteroventral nucleus. Further caudal, relative high level of expression was observed in the majority of thalamic nuclei, including the medial and lateral geniculate, subparafascicular and ventral posteriomedial nuclei. In the hippocampus labeled cells were observed in the pyramidal cell layer of CA1, CA2 and CA3 and scattered cells were also found in the granule cell layer of the dentate gyrus. In the amygdala the highest level of labeling was observed in the medial, central and basolateral nuclei. These studies indicate that IJ-opioid receptor mRNA shows widespread distribution in the rostral forebrain of ovariectomized female rats. Within the POA IJ -receptor mRNA was expressed in areas such as the OVLT, AVPV and MPN, that are important for the control of GnRH and LH secretion. Within the basal hypothalamus tJ -receptor mRNA was expressed in different nuclei including the arcuate, which supports electrophysiological findings of IJ-opioid actions (2). Experiments are in progress to further elucidate the cellular phenotypes that express p-receptor mRNA and the ovarian steroid regulation of the preceptor mRNA (6). (Supported by PHS grants HD16793, DA05158, DA08562)",

year = "1994",

month = nov,

day = "10",

doi = "10.1016/0167-0115(94)90481-2",

language = "English (US)",

volume = "54",

pages = "245--246",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Distribution of μ-opioid receptor mRNA in female rat brain

AU - Rönnekleiv, OK

AU - Bosch, MA

AU - Zhang, G.

AU - Bunzow, JR

AU - Grandy, DK

AU - Kelly, MJ

N1 - Funding Information: mRNA (5), revealed that IJ-opioid receptor mRNA was present within oxytocin-containing cells. At the level of the basal hypothalamus, p-receptor mRNA was expressed in the arcuate, dorsomedial, posterior, and premammillary nuclei. The most extensive signal of IJ -receptor mRNA expression was observed in various nuclei of the thalamus and the medial habenula. Thus, in the anterior part of the thalamus, a high level of expression was seen in the paraventricular nucleus thalamus, parataenial, reuniens and the anteroventral nucleus. Further caudal, relative high level of expression was observed in the majority of thalamic nuclei, including the medial and lateral geniculate, subparafascicular and ventral posteriomedial nuclei. In the hippocampus labeled cells were observed in the pyramidal cell layer of CA1, CA2 and CA3 and scattered cells were also found in the granule cell layer of the dentate gyrus. In the amygdala the highest level of labeling was observed in the medial, central and basolateral nuclei. These studies indicate that IJ-opioid receptor mRNA shows widespread distribution in the rostral forebrain of ovariectomized female rats. Within the POA IJ -receptor mRNA was expressed in areas such as the OVLT, AVPV and MPN, that are important for the control of GnRH and LH secretion. Within the basal hypothalamus tJ -receptor mRNA was expressed in different nuclei including the arcuate, which supports electrophysiological findings of IJ-opioid actions (2). Experiments are in progress to further elucidate the cellular phenotypes that express p-receptor mRNA and the ovarian steroid regulation of the preceptor mRNA (6). (Supported by PHS grants HD16793, DA05158, DA08562)

PY - 1994/11/10

Y1 - 1994/11/10

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U2 - 10.1016/0167-0115(94)90481-2

DO - 10.1016/0167-0115(94)90481-2

M3 - Article

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SN - 0167-0115

VL - 54

SP - 245

EP - 246

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 1

ER -

Distribution of μ-opioid receptor mRNA in female rat brain

ASJC Scopus subject areas

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