Abstract
The distribution of nerve fibers containing immunoreactive substance P (SP), estrogen-stimulated neurophysin (ESN), nicotine-stimulated neurophysin (NSN), oxytocin (OT), and vasopressin (VP) was examined in the epithalamic area of adult male and female macaques. Perfused or immersion-fixed epithalamic tissues, sectioned, and mounted on glass slides were processed through the avidin-biotin immunofluorescence method. Fibers containing immunoreactive SP were observed in the pineal organ along the periphery, in the perivascular space, and dispersed between the pinealocytes. Fibers were often observed in the pineal stalk region, and the habenular nuclei had high concentration of immunoreactive SP. Immunoreactive ESN fibers were observed in the stria medullaris, in the lateral habenula, in the pineal stalk, and in the pineal organ. Within the pineal, fibers containing ESN were present in the perivascular space, often concentrated in the walls of blood vessels, but also dispersed between pineal cells. Fibers containing OT, NSN, and VP were also present in the macaque pineal, but in lower quantities compared with fibers containing ESN. These studies show that the pineal of subhuman primates contain nerve fibers (ESN, NSN, VP, OT) of possibly hypothalamic origin. It also has a rich supply of SP fibers, which might be of habenula origin, peripheral parasympathetic ganglia origin, or both. The functional significance of these peptidergic nerve fibers remains to be determined. However, there are indications that they might be involved in regulation of blood flow and release of secretory products from the pinealocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 259-271 |
| Number of pages | 13 |
| Journal | Journal of Pineal Research |
| Volume | 5 |
| Issue number | 3 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Endocrinology
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Distribution in the macaque pineal of nerve fibers containing immunoreactive substance P, vasopressin, oxytocin, and neurophysins. / Ronnekleiv, Oline.
In: Journal of Pineal Research, Vol. 5, No. 3, 1988, p. 259-271.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution in the macaque pineal of nerve fibers containing immunoreactive substance P, vasopressin, oxytocin, and neurophysins
AU - Ronnekleiv, Oline
PY - 1988
Y1 - 1988
N2 - The distribution of nerve fibers containing immunoreactive substance P (SP), estrogen-stimulated neurophysin (ESN), nicotine-stimulated neurophysin (NSN), oxytocin (OT), and vasopressin (VP) was examined in the epithalamic area of adult male and female macaques. Perfused or immersion-fixed epithalamic tissues, sectioned, and mounted on glass slides were processed through the avidin-biotin immunofluorescence method. Fibers containing immunoreactive SP were observed in the pineal organ along the periphery, in the perivascular space, and dispersed between the pinealocytes. Fibers were often observed in the pineal stalk region, and the habenular nuclei had high concentration of immunoreactive SP. Immunoreactive ESN fibers were observed in the stria medullaris, in the lateral habenula, in the pineal stalk, and in the pineal organ. Within the pineal, fibers containing ESN were present in the perivascular space, often concentrated in the walls of blood vessels, but also dispersed between pineal cells. Fibers containing OT, NSN, and VP were also present in the macaque pineal, but in lower quantities compared with fibers containing ESN. These studies show that the pineal of subhuman primates contain nerve fibers (ESN, NSN, VP, OT) of possibly hypothalamic origin. It also has a rich supply of SP fibers, which might be of habenula origin, peripheral parasympathetic ganglia origin, or both. The functional significance of these peptidergic nerve fibers remains to be determined. However, there are indications that they might be involved in regulation of blood flow and release of secretory products from the pinealocytes.
AB - The distribution of nerve fibers containing immunoreactive substance P (SP), estrogen-stimulated neurophysin (ESN), nicotine-stimulated neurophysin (NSN), oxytocin (OT), and vasopressin (VP) was examined in the epithalamic area of adult male and female macaques. Perfused or immersion-fixed epithalamic tissues, sectioned, and mounted on glass slides were processed through the avidin-biotin immunofluorescence method. Fibers containing immunoreactive SP were observed in the pineal organ along the periphery, in the perivascular space, and dispersed between the pinealocytes. Fibers were often observed in the pineal stalk region, and the habenular nuclei had high concentration of immunoreactive SP. Immunoreactive ESN fibers were observed in the stria medullaris, in the lateral habenula, in the pineal stalk, and in the pineal organ. Within the pineal, fibers containing ESN were present in the perivascular space, often concentrated in the walls of blood vessels, but also dispersed between pineal cells. Fibers containing OT, NSN, and VP were also present in the macaque pineal, but in lower quantities compared with fibers containing ESN. These studies show that the pineal of subhuman primates contain nerve fibers (ESN, NSN, VP, OT) of possibly hypothalamic origin. It also has a rich supply of SP fibers, which might be of habenula origin, peripheral parasympathetic ganglia origin, or both. The functional significance of these peptidergic nerve fibers remains to be determined. However, there are indications that they might be involved in regulation of blood flow and release of secretory products from the pinealocytes.
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M3 - Article
C2 - 2457073
AN - SCOPUS:0023901056
VL - 5
SP - 259
EP - 271
JO - Journal of Pineal Research
JF - Journal of Pineal Research
SN - 0742-3098
IS - 3
ER -