Distribution and effect of iodized poppyseed oil in the liver after hepatic artery embolization: Experimental study in several animal species

Zuxing Kan, Mono Sato, Krassi Ivancev, Barry Uchida, Penny Hedgpeth, Anders Lunderquist, Josef Rosch, Ryusaku Yamada

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

To define the intrahepatic distribution of iodized poppyseed oil and its effect on the liver, hepatic artery embolization (HAE) was performed in five mice, 12 rats, four rabbits, and 21 pigs with the iodized oil alone or in combination with gelatin sponge powder (GSPow) in three rats or gelatin sponge particles (GSPs) in nine pigs. All mice, rats, and rabbits underwent radiography of the upper abdomen and in vivo microscopy of the hepatic periphery during and immediately after injection and 1,4, and 24 hours later. All pigs underwent angiography before and after HAE as well as measurement of portal venous pressure before HAE and 15, 30, 45, and 60 minutes and 4 weeks after HAE. Follow-up radiographs were obtained in 18 pigs. HAE performed with the iodized oil only was well tolerated by the liver, even when high doses were used, likely because of continuous flushing of the sinusoids by high blood flow from peripheral arterioles. When HAE was performed with the iodized oil and GSPow, this blood flow ceased and necrosis developed. The degree of necrosis after HAE with the iodized oil in combination with GSPs was directly associated with the dose of iodized oil. HAE performed with GSPs only did not cause damage.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalRADIOLOGY
Volume186
Issue number3
StatePublished - Mar 1993
Externally publishedYes

Keywords

  • Angiography, contrast media
  • Animals
  • Contrast media, experimental studies
  • Contrast media, fatty acid
  • Contrast media, toxicity, 761.448,761.99
  • Iodine and iodine compounds, 761.448
  • Liver, blood supply

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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