Distinctive clinical characteristics of malignant mesothelioma in young patients

Anish Thomas, Yuanbin Chen, Tinghui Yu, Ammara Gill, Vinay Prasad

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Although considered a disease of the elderly, a subset of patients with mesothelioma are young (<40 years). The goal of this study was to understand their characteristics and outcomes. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract mesothelioma cases (1990-2010). We modeled Kaplan-Meyer survival curves stratified by site of disease, and age of presentation. 2% (207 of 12345) of mesothelioma patients are young. Sex distribution is comparable among the young (51% males, 49% females); males predominated (78%, 22%) in the older cohort. Frequency of pleural and peritoneal mesothelioma are similar in the young (47%, 48% respectively); pleural disease predominated in the old (90%, 9%). Cancer-directed surgeries are more frequent in the young. Regardless of histologic subtype, young patients with pleural (11 vs. 8 months) and peritoneal (not reached vs. 10 months) mesothelioma had significantly improved overall survival. In multivariate analysis, younger age was an independent prognostic factor. Although rare, mesothelioma do occur in the young; their characteristics are distinct from those of older patients. Further studies are needed to understand the interplay between genetic susceptibility and mineral fiber carcinogenesis in the pathogenesis of mesothelioma in the young.

Original languageEnglish (US)
Pages (from-to)16766-16773
Number of pages8
JournalOncotarget
Volume6
Issue number18
DOIs
StatePublished - Jan 1 2015

Keywords

  • Asbestos
  • Incidence among the young
  • Mesothelioma
  • SEER analysis

ASJC Scopus subject areas

  • Oncology

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