Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation

Xiou Cao, Rie Kajino-Sakamoto, Argenia Doss, Alejandro Aballay

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Increasing evidence implies an extensive and universal interaction between the immune system and the nervous system. Previous studies showed that OCTR-1, a neuronal G-protein-coupled receptor (GPCR) analogous to human norepinephrine receptors, functions in sensory neurons to control the gene expression of both microbial killing pathways and the unfolded protein response (UPR) in Caenorhabditis elegans. Here, we found that OCTR-1-expressing neurons, ASH, are involved in controlling innate immune pathways. In contrast, another group of OCTR-1-expressing neurons, ASI, was shown to promote pathogen avoidance behavior. We also identified neuropeptide NLP-20 and AIA interneurons, which are responsible for the integration of conflicting cues and behaviors, as downstream components of the ASH/ASI neural circuit. These findings provide insights into a neuronal network involved in regulating pathogen defense mechanisms in C. elegans and might have broad implications for the strategies utilized by metazoans to balance the energy-costly immune activation and behavioral response. Cao et al. show that chemosensory neurons have the ability to coordinate behavioral and immune responses upon bacterial infections in C. elegans. The underlying mechanisms involve interneurons and neuropeptide signaling and provide insights into tactics that may be used by animals when dealing with pathogen threats.

Original languageEnglish (US)
Pages (from-to)1442-1451
Number of pages10
JournalCell Reports
Volume21
Issue number6
DOIs
StatePublished - Nov 7 2017

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Caenorhabditis elegans
Pathogens
Sensory Receptor Cells
Neuropeptides
Neurons
Interneurons
Avoidance Learning
Unfolded Protein Response
Aptitude
Defense Mechanisms
G-Protein-Coupled Receptors
Bacterial Infections
Adrenergic Receptors
Nervous System
Cues
Immune system
Immune System
Neurology
Gene expression
Gene Expression

Keywords

  • behavioral immunology
  • host-pathogen interaction
  • infection
  • innate immunity
  • neural circuit
  • neural-immune communication
  • p38
  • unfolded protein response
  • UPR
  • xbp-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation. / Cao, Xiou; Kajino-Sakamoto, Rie; Doss, Argenia; Aballay, Alejandro.

In: Cell Reports, Vol. 21, No. 6, 07.11.2017, p. 1442-1451.

Research output: Contribution to journalArticle

Cao, Xiou ; Kajino-Sakamoto, Rie ; Doss, Argenia ; Aballay, Alejandro. / Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation. In: Cell Reports. 2017 ; Vol. 21, No. 6. pp. 1442-1451.
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