Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina

Sowmya Venkataramani, Michiel Van Wyk, Ilya Buldyrev, Benjamin Sivyer, David I. Vaney, William Taylor

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This paper examines the role of inhibition in generating the receptive-field properties of local edge detector (LED) ganglion cells in the rabbit retina. We confirm that the feed-forward inhibition is largely glycinergic but, contrary to a recent report, our data demonstrate that the glycinergic inhibition contributes to temporal tuning for the OFF and ON inputs to the LEDs by delaying the onset of spiking; this delay was more pronounced for the ON inputs (∼340 ms) than the OFF inputs (∼12 ms). Blocking glycinergic transmission reduced the delay to spike onset and increased the responses to flickering stimuli at high frequencies. Analysis of the synaptic conductances indicates that glycinergic amacrine cells affect temporal tuning through both postsynaptic inhibition of the LEDs and presynaptic modulation of the bipolar cells that drive the LEDs. The results also confirm that presynaptic GABAergic transmission contributes significantly to the concentric surround antagonism in LEDs; however, unlike presumed LEDs in the mouse retina, the surround is only partly generated by spiking amacrine cells.

Original languageEnglish (US)
Article numbere88560
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 21 2014

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Amacrine Cells
retina
detectors
Light emitting diodes
Retina
Tuning
rabbits
Rabbits
Detectors
Ganglia
cells
Flickering
Modulation
mice

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. / Venkataramani, Sowmya; Van Wyk, Michiel; Buldyrev, Ilya; Sivyer, Benjamin; Vaney, David I.; Taylor, William.

In: PLoS One, Vol. 9, No. 2, e88560, 21.02.2014.

Research output: Contribution to journalArticle

Venkataramani, Sowmya ; Van Wyk, Michiel ; Buldyrev, Ilya ; Sivyer, Benjamin ; Vaney, David I. ; Taylor, William. / Distinct roles for inhibition in spatial and temporal tuning of local edge detectors in the rabbit retina. In: PLoS One. 2014 ; Vol. 9, No. 2.
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