Distal axonopathy: One common type of neurotoxic lesion

Peter Spencer, H. H. Schaumburg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neurotoxic chemicals commonly produce retrograde degeneration of the axons of long and large nerve fibers in the central and peripheral nervous system. This produces a clinical picture of polyneuropathy in man and animals in which sensory and motor disturbances develop in the feet and hands then progress with time to the legs and arms. Distal axonopathy, as the underlying pathologic process is termed, is one of four principal types of neurotoxic diseases, the others including degeneration of neurons (neuropathy), myelin sheaths (myelinopathy) and damage to the neurovasculature (neurovasculopathy). In the experimental animal, these four types of neurotoxic diseases can be distinguished by examining selected areas of brain and nerve tissues prepared by contemporary methods of tissue fixation. These procedures may form the basis of a new and sensitive assay for neurotoxicity.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalEnvironmental Health Perspectives
VolumeVOL. 26
StatePublished - 1978
Externally publishedYes

Fingerprint

lesion
Animals
Retrograde Degeneration
Tissue Fixation
Tissue
Nerve Tissue
Nerve Degeneration
Polyneuropathies
animal
Peripheral Nervous System
Neurology
Pathologic Processes
nervous system
Myelin Sheath
Nerve Fibers
Neurons
fixation
Axons
brain
Foot

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Distal axonopathy : One common type of neurotoxic lesion. / Spencer, Peter; Schaumburg, H. H.

In: Environmental Health Perspectives, Vol. VOL. 26, 1978, p. 97-105.

Research output: Contribution to journalArticle

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