Dissociation of cortisol and adrenal androgen secretion in patients with secondary adrenal insufficiency

G. B. Cutler, S. E. Davis, R. E. Johnsonbaugh, Donald (Lynn) Loriaux

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Abstract

Plasma cortisol, dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and androstenedione (Δ4-A)were measured by RIA during ACTH infusion in preadrenarchal children with constitutional short stature, normal adults and patients with secondary adrenal insufficiency resulting from hypothalamic-pituitary disease or corticosteroid therapy. The plasma levels of all four steroids were decreased in patients with secondary adrenal insufficiency compared to normal adults, but the decrease in DHA and DHAS was considerably greater than that in cortisol and Δ4-A, resulting in significant decreases in the plasma ratios of DHA to cortisol, DHAS to cortisol, DHA to Δ4-A, and DHAS to Δ4-A (P5 adrenal androgens DHA and DHAS than in the secretion of cortisol and Δ4-A, and that the capacity to secrete cortisol and Δ4-A recovers more rapidly than the capacity to secrete the Δ5 adrenal androgens when corticosteroid therapy is withdrawn.

Original languageEnglish (US)
Pages (from-to)604-609
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume49
Issue number4
Publication statusPublished - 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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