Disseminated mycobacterium immunogenum infection presenting with septic shock and skin lesions in a renal transplant recipient

H. M. Biggs, S. M. Chudgar, Christopher Pfeiffer, K. R. Rice, A. K. Zaas, C. R. Wolfe

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mycobacterium immunogenum is a relatively new species within the Mycobacterium chelonae-Mycobacterium abscessus group of rapidly growing mycobacteria (RGM). M. immunogenum was first characterized in 2001 and, similar to other RGM, is an ubiquitous environmental organism. This organism has most commonly been implicated in cutaneous infection in both healthy and immunosuppressed patients. To our knowledge, this is the first reported case of septic shock in the setting of disseminated M. immunogenum infection. Definitive identification of this organism requires gene sequencing at specialized centers, which may limit its detection. M. immunogenum is resistant to many anti-mycobacterial agents, and treatment can be especially challenging in transplant patients, given potential drug interactions and added toxicities. It is important to distinguish M. immunogenum from other RGM and determine the susceptibility profile to devise a successful treatment plan, particularly in the transplant population in which it can potentially cause severe, disseminated disease.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalTransplant Infectious Disease
Volume14
Issue number4
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Mycobacterium Infections
Mycobacterium
Septic Shock
Kidney
Skin
Mycobacterium chelonae
Transplants
Infection
Drug Interactions
Limit of Detection
Transplant Recipients
Anti-Bacterial Agents
Therapeutics
Population
Genes

Keywords

  • Mycobacterium immunogenum
  • Rapidly growing mycobacteria
  • Renal transplant

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Disseminated mycobacterium immunogenum infection presenting with septic shock and skin lesions in a renal transplant recipient. / Biggs, H. M.; Chudgar, S. M.; Pfeiffer, Christopher; Rice, K. R.; Zaas, A. K.; Wolfe, C. R.

In: Transplant Infectious Disease, Vol. 14, No. 4, 01.08.2012, p. 415-421.

Research output: Contribution to journalArticle

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