Dissecting signaling and functions of adhesion G protein-coupled receptors

Demet Araç, Gabriela Aust, Davide Calebiro, Felix B. Engel, Caroline Formstone, André Goffinet, Jörg Hamann, Robert J. Kittel, Ines Liebscher, Hsi Hsien Lin, Kelly R. Monk, Alexander Petrenko, Xianhua Piao, Simone Prömel, Helgi B. Schiöth, Thue W. Schwartz, Martin Stacey, Yuri A. Ushkaryov, Manja Wobus, Uwe WolfrumLei Xu, Tobias Langenhan

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.

Original languageEnglish (US)
Pages (from-to)1-25
Number of pages25
JournalAnnals of the New York Academy of Sciences
Volume1276
Issue number1
DOIs
StatePublished - Dec 2012

Keywords

  • Autoproteolysis
  • G protein-coupled receptors
  • GPS motif
  • Molecular and genetic analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Araç, D., Aust, G., Calebiro, D., Engel, F. B., Formstone, C., Goffinet, A., Hamann, J., Kittel, R. J., Liebscher, I., Lin, H. H., Monk, K. R., Petrenko, A., Piao, X., Prömel, S., Schiöth, H. B., Schwartz, T. W., Stacey, M., Ushkaryov, Y. A., Wobus, M., ... Langenhan, T. (2012). Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences, 1276(1), 1-25. https://doi.org/10.1111/j.1749-6632.2012.06820.x