TY - JOUR
T1 - Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use
T2 - The Gazel Youth study
AU - Galéra, C.
AU - Bouvard, M. P.
AU - Melchior, M.
AU - Chastang, J. F.
AU - Lagarde, E.
AU - Michel, G.
AU - Encrenaz, G.
AU - Messiah, A.
AU - Fombonne, E.
N1 - Funding Information:
The authors express their thanks to EDF-GDF, especially to the service des études médicales and the service général de médecine de contrôle, and to the “Caisse centrale d’action sociale du personnel des industries électrique et gazière”. We also wish to acknowledge the Risques postprofessionnels – cohortes de l’unité mixte 687 Inserm – CNAMTS team responsible for the Gazel data base management. The authors express their thanks to P. Goldberg from Inserm unit 687, and to Dr Johnston from the Institute for Survey Research, Ann Arbor, MI. The Gazel Cohort Study was funded by EDF-GDF and Inserm, and received grants from the Association de la Recherche sur le Cancer and from the Fondation de France. Funding for this study was provided by a Direction générale de la santé grant and a Mission interministérielle de lutte contre la drogue et la toxicomanie grant to Eric Fombonne.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.
AB - Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.
KW - Attention deficit hyperactivity disorder
KW - Conduct disorder
KW - Epidemiology
KW - Externalizing behavior disorders
KW - Marijuana
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=77958494714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958494714&partnerID=8YFLogxK
U2 - 10.1016/j.eurpsy.2010.06.002
DO - 10.1016/j.eurpsy.2010.06.002
M3 - Article
C2 - 20813507
AN - SCOPUS:77958494714
VL - 25
SP - 402
EP - 408
JO - Psychiatrie et Psychobiologie
JF - Psychiatrie et Psychobiologie
SN - 0924-9338
IS - 7
ER -