Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use: The Gazel Youth study

C. Galéra; M. P. Bouvard; M. Melchior; J. F. Chastang; E. Lagarde; G. Michel; G. Encrenaz; A. Messiah; E. Fombonne

doi:10.1016/j.eurpsy.2010.06.002

Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use: The Gazel Youth study

C. Galéra, M. P. Bouvard, M. Melchior, J. F. Chastang, E. Lagarde, G. Michel, G. Encrenaz, A. Messiah, E. Fombonne

Pediatrics

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.

Original language	English (US)
Pages (from-to)	402-408
Number of pages	7
Journal	European Psychiatry
Volume	25
Issue number	7
DOIs	https://doi.org/10.1016/j.eurpsy.2010.06.002
State	Published - Nov 2010

Keywords

Attention deficit hyperactivity disorder
Conduct disorder
Epidemiology
Externalizing behavior disorders
Marijuana
Tobacco

ASJC Scopus subject areas

Psychiatry and Mental health

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Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use : The Gazel Youth study. / Galéra, C.; Bouvard, M. P.; Melchior, M.; Chastang, J. F.; Lagarde, E.; Michel, G.; Encrenaz, G.; Messiah, A.; Fombonne, E.

In: European Psychiatry, Vol. 25, No. 7, 11.2010, p. 402-408.

Research output: Contribution to journal › Article › peer-review

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title = "Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use: The Gazel Youth study",

abstract = "Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.",

keywords = "Attention deficit hyperactivity disorder, Conduct disorder, Epidemiology, Externalizing behavior disorders, Marijuana, Tobacco",

author = "C. Gal{\'e}ra and Bouvard, {M. P.} and M. Melchior and Chastang, {J. F.} and E. Lagarde and G. Michel and G. Encrenaz and A. Messiah and E. Fombonne",

note = "Funding Information: The authors express their thanks to EDF-GDF, especially to the service des {\'e}tudes m{\'e}dicales and the service g{\'e}n{\'e}ral de m{\'e}decine de contr{\^o}le, and to the “Caisse centrale d{\textquoteright}action sociale du personnel des industries {\'e}lectrique et gazi{\`e}re”. We also wish to acknowledge the Risques postprofessionnels – cohortes de l{\textquoteright}unit{\'e} mixte 687 Inserm – CNAMTS team responsible for the Gazel data base management. The authors express their thanks to P. Goldberg from Inserm unit 687, and to Dr Johnston from the Institute for Survey Research, Ann Arbor, MI. The Gazel Cohort Study was funded by EDF-GDF and Inserm, and received grants from the Association de la Recherche sur le Cancer and from the Fondation de France. Funding for this study was provided by a Direction g{\'e}n{\'e}rale de la sant{\'e} grant and a Mission interminist{\'e}rielle de lutte contre la drogue et la toxicomanie grant to Eric Fombonne.",

year = "2010",

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doi = "10.1016/j.eurpsy.2010.06.002",

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T1 - Disruptive symptoms in childhood and adolescence and early initiation of tobacco and cannabis use

T2 - The Gazel Youth study

AU - Galéra, C.

AU - Bouvard, M. P.

AU - Melchior, M.

AU - Chastang, J. F.

AU - Lagarde, E.

AU - Michel, G.

AU - Encrenaz, G.

AU - Messiah, A.

AU - Fombonne, E.

N1 - Funding Information: The authors express their thanks to EDF-GDF, especially to the service des études médicales and the service général de médecine de contrôle, and to the “Caisse centrale d’action sociale du personnel des industries électrique et gazière”. We also wish to acknowledge the Risques postprofessionnels – cohortes de l’unité mixte 687 Inserm – CNAMTS team responsible for the Gazel data base management. The authors express their thanks to P. Goldberg from Inserm unit 687, and to Dr Johnston from the Institute for Survey Research, Ann Arbor, MI. The Gazel Cohort Study was funded by EDF-GDF and Inserm, and received grants from the Association de la Recherche sur le Cancer and from the Fondation de France. Funding for this study was provided by a Direction générale de la santé grant and a Mission interministérielle de lutte contre la drogue et la toxicomanie grant to Eric Fombonne.

PY - 2010/11

Y1 - 2010/11

N2 - Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.

AB - Purpose: To examine the link between symptoms of hyperactivity-inattention and conduct disorder in childhood, and the initiation of tobacco and cannabis use, controlling for other behavioral symptoms, temperament and environmental risk factors. Method: The sample (N=1107 participants, aged 4 to 18 years at baseline) was recruited from the population-based longitudinal Gazel Youth study with a follow-up assessment 8 years later. Psychopathology, temperament, environmental variables, and initiation of tobacco and cannabis use were self-reported. Event time analyses were performed to assess the effects of childhood disruptive symptoms on age at first use of tobacco and cannabis. Results: Proportional hazard models revealed that participants with high levels of childhood symptoms of both hyperactivity-inattention and conduct disorder were at highest risk of early tobacco initiation (in males: hazard ratio [HR]. =2.05; confidence interval [CI]: 1.24-3.38; in females: HR. =2.01; CI: 1.31-3.09), and, in males, of early cannabis initiation (HR. =1.95; CI: 1.04-3.64). Temperament, through activity in both males and females and negative emotionality in females, was also associated to early substance use initiation. Conclusions: Children who simultaneously have high levels of symptoms of hyperactivity-inattention and conduct disorder are at increased risk for early substance initiation. These associations may guide childhood health professionals to consider the liability for early substance initiation in high-risk groups.

KW - Attention deficit hyperactivity disorder

KW - Conduct disorder

KW - Epidemiology

KW - Externalizing behavior disorders

KW - Marijuana

KW - Tobacco

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