Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'

Katsunori Tomiyama, Yasuyuki Makihara, Hiroshi Yamamoto, Gerard O'Sullivan, Rachel E. Nally, Orna Tighe, Anthony Kinsella, Allen A. Fienberg, David K. Grandy, David R. Sibley, David T. Croke, Noriaki Koshikawa, John L. Waddington

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations


    The role of D1-like [D1, D5] and D2-like [D2, D3, D4] dopamine receptors and dopamine transduction via DARPP-32 in topographies of orofacial movement was assessed in restrained mice with congenic D4 vs. D5 receptor vs. DARPP-32 'knockout'. D4 and DARPP-32 mutants evidenced no material phenotype; also, there were no alterations in topographical responsivity to either the selective D2-like agonist RU 24213 or the selective D1-like agonist SK and F 83959. In contrast, D5 mutants evidenced an increase in spontaneous vertical jaw movements, which habituated more slowly than in wildtypes, and a decrease in horizontal jaw movements; topographical responsivity to SK and F 83959 and RU 24213 was unaltered. D5 receptors regulate distinct topographies of vertical and horizontal jaw movement in an opposite manner. In assuming that the well-recognised role of the D1-like family in regulating orofacial movements involves primarily D1 receptors, a role for their D5 counterparts may have been overlooked.

    Original languageEnglish (US)
    Pages (from-to)437-445
    Number of pages9
    JournalEuropean Neuropsychopharmacology
    Issue number6
    StatePublished - Aug 2006


    • D 'knockout'
    • D 'knockout'
    • DARPP-32 'knockout'
    • Dopamine receptors
    • Orofacial movements
    • Topographical assessment

    ASJC Scopus subject areas

    • Pharmacology
    • Neurology
    • Clinical Neurology
    • Psychiatry and Mental health
    • Biological Psychiatry
    • Pharmacology (medical)


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