@article{abe7bcf98e124149ba17d4aabea784fc,
title = "Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'",
abstract = "The role of D1-like [D1, D5] and D2-like [D2, D3, D4] dopamine receptors and dopamine transduction via DARPP-32 in topographies of orofacial movement was assessed in restrained mice with congenic D4 vs. D5 receptor vs. DARPP-32 'knockout'. D4 and DARPP-32 mutants evidenced no material phenotype; also, there were no alterations in topographical responsivity to either the selective D2-like agonist RU 24213 or the selective D1-like agonist SK and F 83959. In contrast, D5 mutants evidenced an increase in spontaneous vertical jaw movements, which habituated more slowly than in wildtypes, and a decrease in horizontal jaw movements; topographical responsivity to SK and F 83959 and RU 24213 was unaltered. D5 receptors regulate distinct topographies of vertical and horizontal jaw movement in an opposite manner. In assuming that the well-recognised role of the D1-like family in regulating orofacial movements involves primarily D1 receptors, a role for their D5 counterparts may have been overlooked.",
keywords = "D 'knockout', D 'knockout', DARPP-32 'knockout', Dopamine receptors, Orofacial movements, Topographical assessment",
author = "Katsunori Tomiyama and Yasuyuki Makihara and Hiroshi Yamamoto and Gerard O'Sullivan and Nally, {Rachel E.} and Orna Tighe and Anthony Kinsella and Fienberg, {Allen A.} and Grandy, {David K.} and Sibley, {David R.} and Croke, {David T.} and Noriaki Koshikawa and Waddington, {John L.}",
note = "Funding Information: We thank Dr. Paul Greengard, Rockefeller University, New York, for his assistance in obtaining DARPP-32 mutants. These studies were supported by: a Nihon University research grant, research grants from the Sato Fund and the Dental Research Centre, the Promotion and Mutual Aid Corporation for Private Schools of Japan, a grant for promotion of multidisciplinary research projects and grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology, Japan; DA 12062, DA 10044, MH 39327, MH 40899 and the Peter Jay Sharp Foundation, USA; Science Foundation Ireland, Enterprise Ireland and the Stanley Medical Research Institute in the Research Institute of the Royal College of Surgeons in Ireland under the Higher Education Authority's Programme for Research in Third Level Institutions, Ireland. We thank Hoechst–Marion–Roussel for RU 24213. SK and F 83959 was provided initially by RBI and subsequently by SRI as part of the Chemical Synthesis Program of the National Institute of Mental Health.",
year = "2006",
month = aug,
doi = "10.1016/j.euroneuro.2005.11.012",
language = "English (US)",
volume = "16",
pages = "437--445",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "6",
}