Disposable aptamer-sensor aided by magnetic nanoparticle enrichment for detection of salivary cortisol variations in obstructive sleep apnea patients

Renny Edwin Fernandez, Yogeswaran Umasankar, Pandiaraj Manickam, Jeffrey C. Nickel, Laura R. Iwasaki, Burt K. Kawamoto, Kristen C. Todoki, Jo Anna M. Scott, Shekhar Bhansali

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We report a disposable point-of-care sensing platform specific to salivary cortisol detection. The sensor is inkjet printed on a paper substrate with a metalloporphyrin based macrocyclic catalyst ink that can electrochemically reduce cortisol, captured by aptamer functionalized magnetic nanoparticles. The sensor consists of a thin magnet disc, aligned at the back of the electrode, in order to populate the magnetic nanoparticle bound cortisol at the sensing electrode area. Proof of concept studies were performed to detect salivary cortisol levels in human subjects with high and low risks for obstructive sleep apnea (OSA). High selectivity was observed to salivary cortisol against a background of closely related steroids.

Original languageEnglish (US)
Article number17992
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

ASJC Scopus subject areas

  • General

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