Disorders of cochlear blood flow

Tsutomu Nakashima, Shinji Naganawa, Michihiko Sone, Mitsuo Tominaga, Hideo Hayashi, Hiroshi Yamamoto, Xiuli Liu, Alfred L. Nuttall

Research output: Contribution to journalReview article

157 Scopus citations

Abstract

The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalBrain Research Reviews
Volume43
Issue number1
DOIs
StatePublished - Sep 2003

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Keywords

  • Blood flow
  • Cochlea
  • Hearing loss
  • Laser-Doppler flowmetry
  • Magnetic resonance imaging
  • Ultrasonography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Nakashima, T., Naganawa, S., Sone, M., Tominaga, M., Hayashi, H., Yamamoto, H., Liu, X., & Nuttall, A. L. (2003). Disorders of cochlear blood flow. Brain Research Reviews, 43(1), 17-28. https://doi.org/10.1016/S0165-0173(03)00189-9