TY - JOUR
T1 - Disorders of cochlear blood flow
AU - Nakashima, Tsutomu
AU - Naganawa, Shinji
AU - Sone, Michihiko
AU - Tominaga, Mitsuo
AU - Hayashi, Hideo
AU - Yamamoto, Hiroshi
AU - Liu, Xiuli
AU - Nuttall, Alfred L.
N1 - Funding Information:
This study was supported by the Program for the Invitation of Foreign Scientists to Japanese Institutes provided by Japan Foundation for Aging and Health. This study was also supported by United States NIH research grant DC00105 and Japanese Grant-in-Aid for Scientific Research B-11470355,15390515.
PY - 2003/9
Y1 - 2003/9
N2 - The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.
AB - The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.
KW - Blood flow
KW - Cochlea
KW - Hearing loss
KW - Laser-Doppler flowmetry
KW - Magnetic resonance imaging
KW - Ultrasonography
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U2 - 10.1016/S0165-0173(03)00189-9
DO - 10.1016/S0165-0173(03)00189-9
M3 - Review article
C2 - 14499459
AN - SCOPUS:0141676602
SN - 0165-0173
VL - 43
SP - 17
EP - 28
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 1
ER -