Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia

Assessment with serial CT

Thomas E. Hartman, Steven Primack, Eun Young Kang, Stephen J. Swensen, David M. Hansell, Georgeann McGuinness, Nestor L. Müller

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalChest
Volume110
Issue number2
StatePublished - 1996
Externally publishedYes

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Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Disease Progression
Glass
Biopsy

Keywords

  • computed tomography
  • desquamative interstitial pneumonia
  • disease progression
  • usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Hartman, T. E., Primack, S., Kang, E. Y., Swensen, S. J., Hansell, D. M., McGuinness, G., & Müller, N. L. (1996). Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT. Chest, 110(2), 378-382.

Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia : Assessment with serial CT. / Hartman, Thomas E.; Primack, Steven; Kang, Eun Young; Swensen, Stephen J.; Hansell, David M.; McGuinness, Georgeann; Müller, Nestor L.

In: Chest, Vol. 110, No. 2, 1996, p. 378-382.

Research output: Contribution to journalArticle

Hartman, TE, Primack, S, Kang, EY, Swensen, SJ, Hansell, DM, McGuinness, G & Müller, NL 1996, 'Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia: Assessment with serial CT', Chest, vol. 110, no. 2, pp. 378-382.
Hartman, Thomas E. ; Primack, Steven ; Kang, Eun Young ; Swensen, Stephen J. ; Hansell, David M. ; McGuinness, Georgeann ; Müller, Nestor L. / Disease progression in usual interstitial pneumonia compared with desquamative interstitial pneumonia : Assessment with serial CT. In: Chest. 1996 ; Vol. 110, No. 2. pp. 378-382.
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abstract = "To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16{\%}) and irregular lines (mean ± SD extent, 17 ± 7{\%}) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6{\%}). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26{\%}), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5{\%}), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.",
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AU - Hartman, Thomas E.

AU - Primack, Steven

AU - Kang, Eun Young

AU - Swensen, Stephen J.

AU - Hansell, David M.

AU - McGuinness, Georgeann

AU - Müller, Nestor L.

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N2 - To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

AB - To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP). Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HBCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement. Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean ± SD extent, 30 ± 16%) and irregular lines (mean ± SD extent, 17 ± 7%) and 10 patients had honeycombing (mean ± SD extent, 10 ± 6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean ± SD extent, 51 ± 26%), 5 patients had irregular linear opacities (mean ± SD extent, 5 ± 5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=1) or honeycombing (n=1) (p2 test). Conclusion: In patients with UIP, areas of ground- glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.

KW - computed tomography

KW - desquamative interstitial pneumonia

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VL - 110

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