Discriminative stimulus and subjective effects of smoked marijuana in humans

L. D. Chait, S. M. Evans, Kathleen (Kathy) Grant, J. B. Kamien, C. E. Johanson, C. R. Schuster

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The discriminative stimulus (DS) effects of smoked marijuana were studied by training marijuana smokers to discriminate between the effects of marijuana containing 2.7% △9-THC (M) and marijuana containing 0.0% △9-THC (P). In addition to measures of discrimination responding, subjective effects were assessed with standardized mood questionnaires. The post-smoking increase in expired air carbon monoxide (CO) level was used as an index of smoke inhalation. Relative to P cigarettes, M cigarettes increased heart rate and produced changes on eight mood scales. M cigarettes were rated as harsher and more potent than P cigarettes, and produced lower levels of CO than P cigarettes. The P-M discrimination was readily acquired by most subjects. The DS effects of marijuana showed a rapid onset, appearing within 90 s from the beginning of smoking. The DS effects were dose dependent, with 0.9% △9-THC marijuana producing primarily placebo-appropriate discrimination responding, and 1.4% △9-THC marijuana producing 100% drug-appropriate responding. This experimental paradigm could be used to determine whether the DS effects of smoked marijuana would generalize to those of other psychoactive drugs.

Original languageEnglish (US)
Pages (from-to)206-212
Number of pages7
JournalPsychopharmacology
Volume94
Issue number2
DOIs
StatePublished - Feb 1988
Externally publishedYes

Fingerprint

Cannabis
Tobacco Products
Dronabinol
Carbon Monoxide
Smoking
Psychotropic Drugs
Smoke
Inhalation
Heart Rate
Air
Placebos
Pharmaceutical Preparations

Keywords

  • Cannabinoids
  • Carbon monoxide
  • Drug discrimination
  • Humans
  • Marijuana
  • Mood
  • Stimulus effects
  • Subjective effects

ASJC Scopus subject areas

  • Pharmacology

Cite this

Chait, L. D., Evans, S. M., Grant, K. K., Kamien, J. B., Johanson, C. E., & Schuster, C. R. (1988). Discriminative stimulus and subjective effects of smoked marijuana in humans. Psychopharmacology, 94(2), 206-212. https://doi.org/10.1007/BF00176846

Discriminative stimulus and subjective effects of smoked marijuana in humans. / Chait, L. D.; Evans, S. M.; Grant, Kathleen (Kathy); Kamien, J. B.; Johanson, C. E.; Schuster, C. R.

In: Psychopharmacology, Vol. 94, No. 2, 02.1988, p. 206-212.

Research output: Contribution to journalArticle

Chait, LD, Evans, SM, Grant, KK, Kamien, JB, Johanson, CE & Schuster, CR 1988, 'Discriminative stimulus and subjective effects of smoked marijuana in humans', Psychopharmacology, vol. 94, no. 2, pp. 206-212. https://doi.org/10.1007/BF00176846
Chait, L. D. ; Evans, S. M. ; Grant, Kathleen (Kathy) ; Kamien, J. B. ; Johanson, C. E. ; Schuster, C. R. / Discriminative stimulus and subjective effects of smoked marijuana in humans. In: Psychopharmacology. 1988 ; Vol. 94, No. 2. pp. 206-212.
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