Discrimination of ethanol-nicotine drug mixtures in mice: Dual interactive mechanisms of overshadowing and potentiation

Matthew Ford, Aubrey D. McCracken, Natalie L. Davis, Andrey Ryabinin, Kathleen (Kathy) Grant

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Rationale: One possible basis for the proclivity of ethanol and nicotine co-abuse is an interaction between the discriminative stimulus (SD) effects of each drug. Objectives: The current work sought to assess the discriminative control of ethanol and nicotine cues in mice trained with drug mixtures and to determine whether interactive mechanisms of overshadowing and potentiation occur. Methods: Male C57BL/6J mice were trained to discriminate ethanol (1.5 g/kg) alone or ethanol plus nicotine (0.4, 0.8, or 1.2 mg/kg base) in experiment 1 and nicotine (0.8 mg/kg) alone or nicotine plus ethanol (0.5, 1.0, or 2.0 g/kg) in experiment 2. Stimulus generalizations of the training mixtures to ethanol, nicotine, and the drug combination were assessed. Results: Ethanol (1.5 g/kg) retained discriminative control despite the inclusion of a progressively larger nicotine dose within the training mixtures in experiment 1. Although the nicotine SD was overshadowed by ethanol training doses > 0.5 g/kg in experiment 2, nicotine did potentiate the effects of low-dose ethanol. Conclusions: These findings are suggestive of dual mechanisms whereby ethanol (>0.5 g/kg) overshadows the SD effects of nicotine, and at lower doses (D effects is potentiated by nicotine. These mechanisms may contribute to the escalation of concurrent drinking and smoking in a binge-like fashion.

Original languageEnglish (US)
Pages (from-to)537-548
Number of pages12
JournalPsychopharmacology
Volume224
Issue number4
DOIs
StatePublished - Dec 2012

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Nicotine
Ethanol
Pharmaceutical Preparations
Discrimination (Psychology)
Stimulus Generalization
Drug Combinations
Inbred C57BL Mouse
Drinking
Cues
Smoking

Keywords

  • Alcohol
  • Discriminative stimulus
  • Drug discrimination
  • Ethanol
  • Mice
  • Nicotine
  • Overshadowing
  • Potentiation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Discrimination of ethanol-nicotine drug mixtures in mice : Dual interactive mechanisms of overshadowing and potentiation. / Ford, Matthew; McCracken, Aubrey D.; Davis, Natalie L.; Ryabinin, Andrey; Grant, Kathleen (Kathy).

In: Psychopharmacology, Vol. 224, No. 4, 12.2012, p. 537-548.

Research output: Contribution to journalArticle

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