Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging 1

Wei Huang, Luminita A. Tudorica, Xin Li, Sunitha B. Thakur, Yiyi Chen, Elizabeth A. Morris, Ian J. Tagge, Maayan E. Korenblit, William D. Rooney, Jason A. Koutcher, Charles S. Springer

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68 Scopus citations

Abstract

Purpose: To assess the accuracy of the shutter-speed approach compared with standard approach dynamic contrast material-enhanced magnetic resonance (MR) imaging pharmacokinetic analysis for breast cancer diagnosis. Materials and Methods: This study was approved by the institutional review board and was HIPAA compliant. Informed consent was obtained from 89 high-risk women (age range, 28-83 years) who had 92 suspicious lesions with negative findings at mammography (but visible at MR imaging). Each underwent a research dynamic contrast-enhanced MR imaging examination just prior to a clinical MR imaging-guided interventional procedure. Tumor region of interest (ROI) averaged and (for some) pixel-by-pixel dynamic contrastenhanced time-course data, together with mean arterial input function, were subjected to serial standard and shutter-speed approach analyses to extract pharmacokinetic parameters, including rate constant for passive contrast reagent transfer between plasma and interstitium (K trans) and interstitial space volume fraction, or v e. Pathologic findings were used as reference standards. Diagnostic accuracy was assessed with receiver operating characteristic analyses. Results: The pathologic analyses revealed 20 malignant and 72 benign lesions. Positive predictive value of the institutional clinical breast MR imaging protocol was 22%. At 100% sensitivity, ROI-averaged shutter-speed approach K transhad significantly(P = .008) higher diagnostic specificity than standard approach K trans:86.1% versus 77.8%. The difference in the ROI-averaged K trans parameter value, or ΔK trans (≡ K trans [shutter-speed approach] - K trans [standard approach]), had even higher specificity (88.9%). Combined use of ROI analysis and pixel-by-pixel mapping of ΔK trans achieved 98.6% specificity at 100% sensitivity. Conclusion: The use of the shutter-speed dynamic contrast-enhanced MR imaging method has the potential to improve breast cancer diagnostic accuracy and reduce putatively unnecessary biopsy procedures that yield benign pathologic findings.

Original languageEnglish (US)
Pages (from-to)394-403
Number of pages10
JournalRADIOLOGY
Volume261
Issue number2
DOIs
StatePublished - Nov 1 2011

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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