Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists

Brian P. Rowe, Kevin L. Grove, David L. Saylor, Robert C. Speth

    Research output: Contribution to journalArticle

    79 Scopus citations

    Abstract

    The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with 125I-Sar1-Ile8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AIIα subtype) or PD123177 (designated AIIβ subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AIIα and AIIβ subtypes.

    Original languageEnglish (US)
    Pages (from-to)45-53
    Number of pages9
    JournalRegulatory Peptides
    Volume33
    Issue number1
    DOIs
    StatePublished - Mar 26 1991

    Keywords

    • Angiotensin II receptor
    • DuP 753
    • PD123177
    • Rat brain
    • Receptor autoradiography
    • Receptor subtype

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

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